Introduction : In order to evaluate the role of thyroid autoimmunity in patients with goiter, this study was done 10 years after implementation of iodine supplementation program ( iodised salt). The serum levels of thyroid peroxidase antibodies (Anti TPO) and thyroglobulin antibodies (anti TG) were studied in a group of patients with simple goiter and compared with normal controls. Materials and methods: We performed this study at the endocrine clinic of Noor Hospital in Isfahan University using simple sampling method in those patients that had normal thyroid function tests: The patients with simple goiter were enrolled in case group (N =105) and those without goiter in control group (N=85). Results: 34.3% (n=36) in case group and 19.1% (n=17) in control group had elevated Anti TPO titer (p value=0.018). 42.9% (n=45) in case group and 23.6% (n=21) in control group had elevated Anti TG titer (p value=0.005). Discussion : Considering the higher percentage of elevated levels of anti thyroid antibodies in the case group,we conclude that thyroid autoimmunity has an important role in goiter prevalence and increased iodine intake may play a role in thyroid autoimmunity.

Background and Aim: Spontaneous abortion is the most common pregnancy complication with no reasonable causes in most cases. Some research imply the role of antithyroid antibodies (e.g.AntiTPO-Ab and AntiTG-Ab) that can cause spontaneous abortion. In the present study, the association between abortion and presence of antthyroid antibodies in mother’s serum was assessed.Materials and Methods: In this case control study, 102 women aged 15-45 years, who referred to Hajar hospital of Shahrekord or the clinic affiliated to Shahrekord University of Medical Sciences were selected. Out of 102 women, 51 who had had abortion selected as the cases and 51 pregnant women with gestational age less than 20 weeks were include as the controls. In order to assess antithyroid antibodies level, blood samples were taken from every participant with normal TSH level.. Anti-thyroid peroxidase antibody (Anti- TPO-Ab)>50 IU/ml and anti-thyroglobulin antibody (Anti-TG-Abs)>75 IU/ml were defined as Positive. The obtained results were analyzed by means of t-test and 2, using statistical SPSS software.Results: Out of 51 subjects, 18 had positive Anti-TPO-Ab, of which -10 were among the cases and 8 belonged to the controls. Out of 18 women with positive AntiTG-Ab, 11 cases were in the control group and 7 were in the cases. The differences between the control group and the amounts of Anti-TPO-Abs (P=0.468) and Anti-TG-Abs (P=0.675) were not swignificant.Conclusion: The results revealed that there is no association between abortion and presence of antithyroid antibodies in mother’s serum. Other abortion causes such as various kinds of infections and smoking might be involved which requires more research.

Background & Aim: Celiac disease is an autoimmune disorder involving the small intestine caused by gluten consumption. In addition to the complications caused by the involvement of the digestive system, many autoimmune complications, especially autoimmune thyroid diseases, are also common in these patients. The aim of this study was to investigate the prevalence of autoimmune thyroid diseases in celiac children of Urmia for the optimal management of their treatment. Materials & Methods: In this cross-sectional study, venous blood samples were taken from children living in Urmia whose celiac disease was previously confirmed. Anti-transglutaminase test (anti-tTG-) to confirm the diagnosis, Antithyroid Peroxidase antibody (anti-TPO) and Antithyroglobulin Antibody (anti-TG) tests to screen for autoimmune thyroid disease, and Thyroid stimulating hormone (TSH) test was performed to check thyroid function, all by ELISA method. Data were analyzed using descriptive statistics and chi-square test. Results: Seventy-seven patients with an average age of 11. 84 participated in the study,30 of them were male and 47 were female. Anti-TPO test was positive in 3. 9% and Anti-TG test was positive in 11. 7% of the patients, all of whom were female. The difference in both genders regarding Anti-TG was statistically significant (p=0. 023). In most of the patients who had positive Anti-TPO, the Anti-TG test was also positive, and a significant positive correlation was seen between these two tests (R=0. 82). In 26% of the patients, hypothyroidism and in 1. 3% of them, hyperthyroidism was seen. Hypothyroidism was seen in celiac patients in whom Anti-TPO was positive, 66. 7% and in those who Anti-TG was positive, hypothyroidism was seen in 45. 5%, which were not statistically significant (p=0. 12). Conclusion: The results of this study showed that thyroid autoimmune diseases are high in celiac children, especially in females. Therefore, regular examination of thyroid function and monitoring autoantibodies in celiac patients seems necessary for optimal management of both conditions.

Background: Type 1 diabetes is the most common metabolic disease worldwide. Thyroid autoimmune diseases is the most common endocrinopathy in diabetes type 1.Therefore, assessment of thyroid function tests and anti thyroid antibodies in diabetic patients (type 1) is beneficial in early.Objective: The purpose of this study was to compare the anti-thyroid antibodies in diabetic children (type 1) with healthy children.Methods: In this descriptive-analytic study, 65 children with Type 1 diabetes and 65 healthy children who had referred to Children's Hospital in Qazvin were selected by simple sampling. Anti-TG, Anti-TPO, TSH and T4 were measured in both groups. Chi-square, t-independent and Kruskal Valis was used for statistical analysis.Findings. : The difference between sex and age in both groups (case and control) was not significant but BMI percentile was significantly different. Positive Anti-TG was 10.8% in patients and was 1.5% in controls. The difference was statistically significant (p=0.029).16.9% of patients and 3.1% of controls had positive Anti-TPO (p=0.024).10.8% of patients had increased TSH and decreased T4 level (Overt Hypothyroidism).4.6% of controls had increased TSH and normal T4 level (Subclinical Hypothyroidism). The difference was statistically significant for T4.Conclusion: It seems that the prevalence of Hashimoto thyroiditis in patients with type 1 diabetes is more than healthy people. Hence, evaluation of thyroid function tests (TFT) and antithyroid antibodies (Anti-TPO) is necessary to diagnosis and treatment of autoimmune thyroid disorders.

Introduction: Considering the higher prevalence of autoimmune thyroid disorders in iodine replete areas and implementation of an adequate and sustainable IDD control program in Iran, this study was performed to investigate and compare the prevalence of antithyroperoxidase (TPO-Ab) and antithyroglobuline (Tg-Ab) autoantibodies among a control group and patients with hypothyroidism, hyperthyroidism and simple goiter. Materials and Methods: Serum T4, T3, TSH, TPO-Ab and Tg-Ab were measured in 1019 females, 20-50 years old, with and without thyroid dysfunction (control group=130, hypothyroid=379, hyperthyroid=195, simple goiter=315). The results were analyzed using t-test, Chi-square and ANOVA statistical methods. Results: In the control group, 67.7% were found to be negative for autoantibodies, as compared to 45.5%, 35.5%, and 17.4% of patients with simple goiter, hypothyroidism and hyperthyroidism, respectively ( P= 0.000001). The difference observed in the prevalence of TPO-Ab among the 4 groups was significant ( P=0.00001) and the highest prevalence was observed in hyperthyroid cases. The difference in the prevalence of TgAb and both TgAb and TPOAb between the 4 groups was not significant (P>0.05), but the means of TPOAb and TgAb in these groups differed significantly (P=0.00001). In patients with simple goiter and hypothyroidism, the prevalence of autoantibodies increased with age ( P<0.0001). Conclusion: The higher prevalence of TPO-Ab among patients with thyroid dysfunction confirms the pathogenic role of TPO-Ab in autoimmune and non-autoimmune thyroid disorders, although the role of Tg-Ab cannot be ignored.