Purpose: Today, cancer is one of the main causes of death in the world. Moreover, one of the top three causes of death in developed countries and Iran is cancer. Women account for 48% of all cancer cases in Khorasan Razavi province. Given the important role of this group in society, we decided to analyze the incidence of common cancers between 2012-2015. Methods: The present study is a longitudinal study. The data used in this study were extracted from the cancer registration system of Khorasan Razavi province between 2012-2015. This information is related to 11715 female patients with 11 common cancers in this province during the study period. In this study, we investigated the incidence of central nervous system, bladder, lung, breast, colon, leukemia and blood, oesophagus, ovary, skin, stomach, thyroid cancers. MlwiN (version 2. 1) and GIS software (version 10) were used to analyze data and to draw the geographic map, respectively. Results: Among the 11 cancers studied, the highest to lowest four years mean incidence rate were belonged to breast (38. 28), skin (13. 40), stomach (10. 36), colon (9. 77), esophagus (9. 41), lung (5. 02), leukemia and blood (4. 67), thyroid (4. 65), ovary (3. 86), bladder (3. 34) and central nervous system (2. 03) cancers, respectively. Conclusion: Due to the high incidence of breast, skin and stomach cancers among women living in Khorasan Razavi province, it is recommended that the necessary methods to prevent, screen and treat these cancers should be taken into accounbt.