Preventive Role of Cannabinoids Derivate against Methylphenidate‑, Induced Oxidative Stress and Inflammation: The Hypothetical Function of Keap1/Nrf2/ARE Signaling and Proposal of a Treatment Strategy for Neurodegeneration (Editorial)

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Sepehr Afrah; TAHERI FERESHTEH; Kandezi Niyoosha; MOTAGHINEJAD MAJID; Safari Sepideh; Mohammadi Nilofar

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Journal: International Journal of Preventive Medicine Year:2021 | Volume:12 | Issue:- Page(s): 0-0

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Title

Preventive Role of Cannabinoids Derivate against Methylphenidate‑, Induced Oxidative Stress and Inflammation: The Hypothetical Function of Keap1/Nrf2/ARE Signaling and Proposal of a Treatment Strategy for Neurodegeneration (Editorial)

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Abstract

Hypothesis Chronic methylphenidate abuse or administration causes oxidative stress, inflammation, and mitochondrial dysfunction in brain cells that require therapeutic approaches to inhibit neurotoxicity and neurodegeneration of these types. [1, 2] Nonetheless, the function of methylphenidate in the induction of neurodegeneration or neuroprotection is uncertain, but most of the data support the function of methylphenidate in neurodegeneration. [3] As we know, Nrf2 (nuclear erythroid 2‑, related factor 2) is a basic region of leucine‑, zipper transcription factor that binds to the antioxidant response element (ARE) and thus regulates the expression of a large number of genes involved in cellular antioxidant and antiinflammatory defense as well as mitochondrial protection. [4, 5] Keap1 (Kelch ECH associating protein 1) is a repressor protein which binds to Nrf2 and promotes its degradation through the pathway of ubiquitin‑, proteasome...

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APA: Copy

Sepehr, Afrah, TAHERI, FERESHTEH, Kandezi, Niyoosha, MOTAGHINEJAD, MAJID, Safari, Sepideh, & Mohammadi, Nilofar. (2021). Preventive Role of Cannabinoids Derivate against Methylphenidate‑, Induced Oxidative Stress and Inflammation: The Hypothetical Function of Keap1/Nrf2/ARE Signaling and Proposal of a Treatment Strategy for Neurodegeneration (Editorial). INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 12(-), 0-0. SID. https://sid.ir/paper/994331/en

Vancouver: Copy

Sepehr Afrah, TAHERI FERESHTEH, Kandezi Niyoosha, MOTAGHINEJAD MAJID, Safari Sepideh, Mohammadi Nilofar. Preventive Role of Cannabinoids Derivate against Methylphenidate‑, Induced Oxidative Stress and Inflammation: The Hypothetical Function of Keap1/Nrf2/ARE Signaling and Proposal of a Treatment Strategy for Neurodegeneration (Editorial). INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2021;12(-):0-0. Available from: https://sid.ir/paper/994331/en

IEEE: Copy

Afrah Sepehr, FERESHTEH TAHERI, Niyoosha Kandezi, MAJID MOTAGHINEJAD, Sepideh Safari, and Nilofar Mohammadi, “Preventive Role of Cannabinoids Derivate against Methylphenidate‑, Induced Oxidative Stress and Inflammation: The Hypothetical Function of Keap1/Nrf2/ARE Signaling and Proposal of a Treatment Strategy for Neurodegeneration (Editorial),” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 12, no. -, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/994331/en

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