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Information Journal Paper

Title

The effects of sildenafil on the hippocampal longterm potentiation in male rats

Pages

  138-144

Abstract

 Introduction: The hippocampal nitric oxide/cGMP signaling pathway plays a crucial role in memory processing. Phosphodiesterase interacts with this signaling pathway. There are controversial reports regarding the effect of sildenafil, a phosphodiesterase inhibitor, on learning and memory. Therefore, the effects of acute administration (intrahippocampal/ intra-dentate gyrus injection) of sildenafil on long-term potentiation (LTP) of rats were investigated. Methods: The rats were anesthetized with urethane and placed in a stereotaxic device for field potential recording. After ensuring a steady-state baseline response, a single intraperitoneal injection of saline or sildenafil (2 and10 μ g/kg) was done. The population spike amplitude, the excitatory postsynaptic potentials (EPSPs) slope and paired-pulse stimuli (as an inhibitory interneuron) were compared between groups. Results: The results showed that population spike amplitude and EPSP slope significantly increased after sildenafil administration (10μ g/kg) following titanic stimulation compared with the saline group. However, the sildenafil (2μ g/kg) and control groups showed no difference regarding population spike amplitude and EPSP slope. Sildenafil had no significant effects on recurrent inhibition. Conclusion: The obtained results indicated that acute administration of sildenafil improved LTP via direct effects on the hippocampus of intact rats. Thus, sildenafil may enhance learning and memory processing by modulating the hippocampal synapse.

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    APA: Copy

    SHAHIDI, SIAMAK, VISHTEH, MINA, KOMAKI, ALIREZA, & Sadeghian, Reihaneh. (2022). The effects of sildenafil on the hippocampal longterm potentiation in male rats. PHYSIOLOGY AND PHARMACOLOGY, 26(2), 138-144. SID. https://sid.ir/paper/978310/en

    Vancouver: Copy

    SHAHIDI SIAMAK, VISHTEH MINA, KOMAKI ALIREZA, Sadeghian Reihaneh. The effects of sildenafil on the hippocampal longterm potentiation in male rats. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2022;26(2):138-144. Available from: https://sid.ir/paper/978310/en

    IEEE: Copy

    SIAMAK SHAHIDI, MINA VISHTEH, ALIREZA KOMAKI, and Reihaneh Sadeghian, “The effects of sildenafil on the hippocampal longterm potentiation in male rats,” PHYSIOLOGY AND PHARMACOLOGY, vol. 26, no. 2, pp. 138–144, 2022, [Online]. Available: https://sid.ir/paper/978310/en

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