Prognostic Impact of Circulating CD28 Negative Suppressor T Cells and Memory B Cells on Treatment Outcomes of Patients with Breast Cancer

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Zahran Asmaa M.; Shaltout Asmaa S.; FAKHRY HUSSEIN; Khallaf Salah M.; Abdel Fattah Ola N.; Temerik Doaa F.; Rayan Amal

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF IMMUNOLOGY Year:2020 | Volume:17 | Issue:2 Page(s): 95-110

Download Full-Text

View:

175

Download:

124

Cites:

Information Journal Paper

Title

Prognostic Impact of Circulating CD28 Negative Suppressor T Cells and Memory B Cells on Treatment Outcomes of Patients with Breast Cancer

Author(s)

Keywords

NK Cells

NKT Cells

B-Cells

T-Cells

Breast Cancer

Abstract

Background: Circulating lymphocytes can put up understanding of the interactions between tumor cells and lymphocytes infiltrating the tumor microenvironment. Objective: In this sense, the prognostic value of the inflammatory cell in breast cancer (BC) peripheral blood needs to be evaluated; this would suggest that estimation and evaluation of these circulating lymphocytes could provide a prognostic value in BC. Methods: The present study was a prospective case-control study, 30 Patients with operable breast cancer; any T, any N, M0, treated surgically with either modified radical mastectomy or breast conservative surgery, and 20 healthy controls were included. For detection of lymphocyte subsets in peripheral blood; Fluorochrome-labeled monoclonal primary antibodies were used, the cells were analyzed by FACSCalibur flow cytometry with Cell Quest software, then patients were treated with chemotherapy, 3DCRT, and hormonal treatment, and followed up to determine relapses and recurrence-free survival (RFS). Results: Significant differences of different cell types B, T, NK, NKT, and CD28-T between BC patients and controls, significant differences of CD8+CD28-cells among different biologic subtypes, negative correlations between CD8+CD28-cells and memory B cells, and RFS. Significant differences of naï ve B cells among different grades of BC, and negative correlation between B cells and NKT cells. Conclusion: NK, NKT, lymphocytes, and CD28-Tcells significantly differed between healthy controls and BC patients; also, different B cells were associated with good response to treatment while CD28-cells were associated with shorter RFS.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

Zahran, Asmaa M., Shaltout, Asmaa S., FAKHRY, HUSSEIN, Khallaf, Salah M., Abdel Fattah, Ola N., Temerik, Doaa F., & Rayan, Amal. (2020). Prognostic Impact of Circulating CD28 Negative Suppressor T Cells and Memory B Cells on Treatment Outcomes of Patients with Breast Cancer. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 17(2), 95-110. SID. https://sid.ir/paper/764293/en

Vancouver: Copy

Zahran Asmaa M., Shaltout Asmaa S., FAKHRY HUSSEIN, Khallaf Salah M., Abdel Fattah Ola N., Temerik Doaa F., Rayan Amal. Prognostic Impact of Circulating CD28 Negative Suppressor T Cells and Memory B Cells on Treatment Outcomes of Patients with Breast Cancer. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2020;17(2):95-110. Available from: https://sid.ir/paper/764293/en

IEEE: Copy

Asmaa M. Zahran, Asmaa S. Shaltout, HUSSEIN FAKHRY, Salah M. Khallaf, Ola N. Abdel Fattah, Doaa F. Temerik, and Amal Rayan, “Prognostic Impact of Circulating CD28 Negative Suppressor T Cells and Memory B Cells on Treatment Outcomes of Patients with Breast Cancer,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 17, no. 2, pp. 95–110, 2020, [Online]. Available: https://sid.ir/paper/764293/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops