Influence of Four Phlomis Species on Melanogenesis in Human Malignant Melanoma (SKMEL-3) Cells

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SARKHAIL PARISA; SALIMI MONA; SAEIDNIA SOODABEH; NIKAN MARJAN; Kurpaz mahmoodabadi Mahdieh

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Journal: RESEARCH JOURNAL OF PHARMACOGNOSY Year:2019 | Volume:6 | Issue:2 Page(s): 19-24

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Title

Influence of Four Phlomis Species on Melanogenesis in Human Malignant Melanoma (SKMEL-3) Cells

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Keywords

cytotoxicity

melanogenesis

Phlomis species

SKMEL-3 cells

tyrosinase

Abstract

Background and objectives: Phytochemical studies have shown that the Phlomis species are rich in polyphenolics and iridoid glycosides and many of them have shown potential value in different biological and pharmacological activities. In this study, we evaluated the effect of Phlomis persica, P. brugieri, P. olivieri and P. anisodontea extracts on melanin production in human malignant melanoma (SKMEL-3) cells. Methods: The anti-tyrosinase activity of the extracts was investigated using mushroom tyrosinase assay. Cytotoxicity potentials were examined through MTT assay on SKMEL-3 cell line and then the level of melanin formation in SKMEL-3 cells was determined. Results: The anti-tyrosinase activity of the Phlomis extracts was not remarkable (about 0. 1 mg/mL). All extracts significantly increased the melanin content in SKMEL-3 cells at 0. 25 mg/mL and among them P. anisodontea extract seemed to be more efficient in stimulating melanin production. Conclusion: Based on our results, we suggest these total extracts particularly P. anisodontea extract contain the potent skin browning agents that can be used in pharmaceutical and cosmetic products.

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APA: Copy

SARKHAIL, PARISA, SALIMI, MONA, SAEIDNIA, SOODABEH, NIKAN, MARJAN, & Kurpaz mahmoodabadi, Mahdieh. (2019). Influence of Four Phlomis Species on Melanogenesis in Human Malignant Melanoma (SKMEL-3) Cells. RESEARCH JOURNAL OF PHARMACOGNOSY, 6(2), 19-24. SID. https://sid.ir/paper/755650/en

Vancouver: Copy

SARKHAIL PARISA, SALIMI MONA, SAEIDNIA SOODABEH, NIKAN MARJAN, Kurpaz mahmoodabadi Mahdieh. Influence of Four Phlomis Species on Melanogenesis in Human Malignant Melanoma (SKMEL-3) Cells. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2019;6(2):19-24. Available from: https://sid.ir/paper/755650/en

IEEE: Copy

PARISA SARKHAIL, MONA SALIMI, SOODABEH SAEIDNIA, MARJAN NIKAN, and Mahdieh Kurpaz mahmoodabadi, “Influence of Four Phlomis Species on Melanogenesis in Human Malignant Melanoma (SKMEL-3) Cells,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 6, no. 2, pp. 19–24, 2019, [Online]. Available: https://sid.ir/paper/755650/en

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