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Information Journal Paper

Title

Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice

Pages

  45-51

Abstract

 Background and objectives: Menopause is associated with depression as well as emotional and memory disorders. Based on the anti-inflammatory and antioxidant effects of pistachio, its effect on depression, cognitive function, anxiety and physical power in ovariectomized mice was investigated. Methods: In the current study, fifty female mice were used. They were aliquoted into five groups: control, ovariectomy (OVX), ovariectomy + DMSO, ovariectomy +10 mg/kg pistachioextract and Ovariectomy +100 mg/kg pistachio extract. In order to prepare the required extract, pistachio nuts were powdered (100 g) and macerated in 1 L of ethanol (80%) for 72 h. Pistachio extract was used orally once a day in ovariectomized mice for sixty days. Anxiety, depression, working memory and physical power were evaluated by the Elevated plus-maze (EPM) test, Forced swimming test (FST), Y maze and swimming exhaustion test, respectively. Results: The results showed that extract of pistachio (more potentially at the dose of 100 mg/kg) decreased anxiety-like behaviors and depression; besides, increase in working memory and physical power was observed in the ovariectomized mice. Conclusion: The findings of the current investigation suggest that pistachio extract could be used as a potential strategy for the attenuation of ovariectomy-related manifestation.

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    APA: Copy

    HAKIMIZADEH, ELHAM, Jandaghi, Faezeh, Hajmohammadi, Mojdeh, FATEMI, IMAN, KAEIDI, AYAT, SHAMSIZADEH, ALI, & ALLAHTAVAKOLI, MOHAMMAD. (2019). Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice. RESEARCH JOURNAL OF PHARMACOGNOSY, 6(4), 45-51. SID. https://sid.ir/paper/751692/en

    Vancouver: Copy

    HAKIMIZADEH ELHAM, Jandaghi Faezeh, Hajmohammadi Mojdeh, FATEMI IMAN, KAEIDI AYAT, SHAMSIZADEH ALI, ALLAHTAVAKOLI MOHAMMAD. Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2019;6(4):45-51. Available from: https://sid.ir/paper/751692/en

    IEEE: Copy

    ELHAM HAKIMIZADEH, Faezeh Jandaghi, Mojdeh Hajmohammadi, IMAN FATEMI, AYAT KAEIDI, ALI SHAMSIZADEH, and MOHAMMAD ALLAHTAVAKOLI, “Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 6, no. 4, pp. 45–51, 2019, [Online]. Available: https://sid.ir/paper/751692/en

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