مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

156
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

154
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Reduced IKK/NF-kB Expression by Nigella Sativa Extract in Breast Cancer

Author(s)

 Kordestani Zeinab | Shahrokhi Farjah Mariam | Yazdi Rouholamini Seyede Elmeira | SABERI AREZOO | Issue Writer Certificate 

Pages

  150-158

Abstract

 Background: Activation of IKK/NF-kB signaling pathway plays a critical role in inflammation-driven tumor progression. Several natural compounds able to inhibit the IKK/NF-kB activation pathway have been shown to either prevent cancer or inhibit cell growth. Extensive studies have been carried out on the Nigella sativa (N. sativa) by many researchers, and its pharmacological activities including anticancer, analgesic, and anti-inflammatory functions have been explored. This study investigated the effect of N. sativa extract on the mRNA level of NFk (p50, RelB) and IKK (IKKA, IKKB) to determine one of the anti-inflammatory mechanisms of N. sativa in Breast cancer cells. Methods: In this experimental study, MCF7 cell line was treated with different concentrations of hydroalcoholic extracts of N. sativa (0, 200, 400, 600, 800 μ g/mL) for 24, 48 and 72 h. Effects of the extract on cell viability and NFk (p50, RelB ) and IKK (IKKA, IKKB) gene expression were analyzed by MTT assay and real time PCR, respectively. Results: mRNA expression levels of NFk (p50, RelB) and IKK (IKKA, IKKB) in the treatment group were lower than the untreated (control) group. Fold difference (p50, RelB) of gene expressions in treatment groups were statistically significant (P =0. 001 and P =0. 003) and the fold difference of IKK (IKKA, IKKB) in the treatment groups was lower than that of the untreated groups (P=0. 01 and P=0. 001). Conclusion: One possible anti-inflammatory mechanism of N. sativa is associated with the reduction in mRNA levels of NFk (p50, RelB) and IKK (IKKA, IKKB) in Breast cancer.

Multimedia

  • No record.

    • Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Kordestani, Zeinab, Shahrokhi Farjah, Mariam, Yazdi Rouholamini, Seyede Elmeira, & SABERI, AREZOO. (2020). Reduced IKK/NF-kB Expression by Nigella Sativa Extract in Breast Cancer. MIDDLE EAST JOURNAL OF CANCER, 11(2), 150-158. SID. https://sid.ir/paper/746565/en

    Vancouver: Copy

    Kordestani Zeinab, Shahrokhi Farjah Mariam, Yazdi Rouholamini Seyede Elmeira, SABERI AREZOO. Reduced IKK/NF-kB Expression by Nigella Sativa Extract in Breast Cancer. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2020;11(2):150-158. Available from: https://sid.ir/paper/746565/en

    IEEE: Copy

    Zeinab Kordestani, Mariam Shahrokhi Farjah, Seyede Elmeira Yazdi Rouholamini, and AREZOO SABERI, “Reduced IKK/NF-kB Expression by Nigella Sativa Extract in Breast Cancer,” MIDDLE EAST JOURNAL OF CANCER, vol. 11, no. 2, pp. 150–158, 2020, [Online]. Available: https://sid.ir/paper/746565/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button