Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus

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Lasom Supakanya; Komanasin Nantarat; Settasatian Nongnuch; Settasatian Chatri; Kukongviriyapan Upa; Intharapetch Pongsak

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2018 | Volume:23 | Issue:7 Page(s): 0-0

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Title

Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus

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Keywords

A disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13

coronary stenosis

diabetes mellitus

polymorphism

Abstract

Background: The imbalance of von Willebrand factor (vWF) and a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 (ADAMTS13) has been associated with atherosclerosis progression. A high level of vWF which regulates thrombus formation is associated with diabetes mellitus (DM), and some ADAMTS13 and vWF polymorphisms have effects on their levels. Therefore, this study aimed to evaluate the associations of ADAMTS13 and vWF polymorphisms and their levels with DM and severity of coronary stenosis. Materials and Methods: Eighty‑ seven DM and 84 control individuals were recruited. vWF and ADAMTS13 activities as well as vWF antigen were measured by collagen‑ binding assay (CBA), residual‑ CBA, and in‑ house enzyme‑ linked immunosorbent assay, respectively. ADAMTS13 and vWF polymorphisms were determined by polymerase chain reaction‑ restriction fragment length polymorphism. Results: The E and G alleles and AA genotype of ADAMTS13 Q448E, rs2073932, and rs652600, respectively, were independently associated with DM (odds ratio [OR] [95% confidence interval (CI)] = 2. 5 [1. 1, 5. 6], 2. 3 [1. 0, 5. 2], and 4. 7 [1. 2, 18. 6], respectively). Moreover, E allele and AA genotype of Q448E and rs652600 were also significantly associated with multi‑ vessel disease (OR [95% CI] = 2. 2 [1. 0, 4. 8] and 3. 2 [1. 0, 10. 0], respectively), while the E and G allele of Q448E and rs2073932 were associated with high Gensini score (OR [95% CI] = 2. 3 [1. 1, 4. 9] and 2. 3 [1. 1, 5. 1], respectively). Conclusion: Association of ADAMTS13 polymorphisms with DM, number of vessel stenosis, and Gensini score may indicate the possible contribution of ADAMTS13 polymorphisms to atherosclerosis progression and severity of coronary stenosis in DM.

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References

Protective effect of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 haplotype on coronary artery disease

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APA: Copy

Lasom, Supakanya, Komanasin, Nantarat, Settasatian, Nongnuch, Settasatian, Chatri, Kukongviriyapan, Upa, & Intharapetch, Pongsak. (2018). Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 23(7), 0-0. SID. https://sid.ir/paper/724285/en

Vancouver: Copy

Lasom Supakanya, Komanasin Nantarat, Settasatian Nongnuch, Settasatian Chatri, Kukongviriyapan Upa, Intharapetch Pongsak. Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2018;23(7):0-0. Available from: https://sid.ir/paper/724285/en

IEEE: Copy

Supakanya Lasom, Nantarat Komanasin, Nongnuch Settasatian, Chatri Settasatian, Upa Kukongviriyapan, and Pongsak Intharapetch, “Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 23, no. 7, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/724285/en

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