مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ANTINOCICEPTIVE EFFECT OF PROMETHAZINE IN MICE

Pages

  140-145

Abstract

 Objective(s): The present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice.Materials and Methods: Antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin ain tests.Results: Promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant inhibition of the second phase response in the formalin pain model (P<0.05) and the drug couldn’t show an antinociceptive effect in the first phase. Morphine (10 mg/kg) inhibited both first and second phase response (P<0.01). Drug also showed a dose-dependent inhibition of acetic acid-induced abdominal writhes. The tail flick and hot plate latency weren’t different from control (P>0.05) and administration of naloxone (0.1 mg/kg) couldn't block the antinociceptive effect of promethazine.Conclusion: The data obtained suggest that antinociceptive effects of the promethazine may be mediated via peripheral and not central mechanisms.

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    APA: Copy

    FARSHCHI, AMIR, GHIASI, G., MALEK KHATABI, P., FARZAEI, HOSSEIN, & NIAYESH, A.. (2009). ANTINOCICEPTIVE EFFECT OF PROMETHAZINE IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 12(3-4 (43)), 140-145. SID. https://sid.ir/paper/561737/en

    Vancouver: Copy

    FARSHCHI AMIR, GHIASI G., MALEK KHATABI P., FARZAEI HOSSEIN, NIAYESH A.. ANTINOCICEPTIVE EFFECT OF PROMETHAZINE IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2009;12(3-4 (43)):140-145. Available from: https://sid.ir/paper/561737/en

    IEEE: Copy

    AMIR FARSHCHI, G. GHIASI, P. MALEK KHATABI, HOSSEIN FARZAEI, and A. NIAYESH, “ANTINOCICEPTIVE EFFECT OF PROMETHAZINE IN MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 12, no. 3-4 (43), pp. 140–145, 2009, [Online]. Available: https://sid.ir/paper/561737/en

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