A COMPARISON OF OCULAR HYPOTENSIVE RESPONSE TO BETAXOLOL AND TIMOLOL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAMMAD RABI H.; RAJAVI ZH.; RAHMATI KAMEL M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: BINA Year:2002 | Volume:7 | Issue:3 Page(s): 236-245

Download Full-Text

View:

235

Download:

Cites:

Information Journal Paper

Title

A COMPARISON OF OCULAR HYPOTENSIVE RESPONSE TO BETAXOLOL AND TIMOLOL

Author(s)

MOHAMMAD RABI H. | RAJAVI ZH. | RAHMATI KAMEL M.

Keywords

BETAXOLOL

TIMOLOL

INTRAOCULAR PRESSURE

PRIMARY OPEN ANGLE GLAUCOMA

OCULAR HYPERTENSION

Abstract

Purpose: To compare the efficacy and side effects of betaxolol and timolol in treatment of primary open angle glaucoma or ocular hypertension.Patients and methods: This single-blind randomized cross-over clinical trial was conducted on 14 patients with primary open angle glaucoma or ocular hypertension. Each patient received timolol 0.5% and betaxolol 0.5% (Sina Darou) twice daily for two weeks in two phases. Before and between the two courses of treatment there was a wash-out period. At the end of the study the effect of these two drugs on intraocular pressure (IOP), mean arterial blood pressure, pulse rate, and basic tear secretion in addition to ocular symptoms were evaluated and statistically analyzed.Results: The study was performed on 14 patients with baseline IOP of 26.7±1.5 mmHg. After 2 weeks of treatment, timolol and betaxolol reduced IOP by 7.8±1.2 mmHg (29%) and 6.1±1.3 mmHg (23%), respectively (P<0.001) and the difference between the two groups was also significant (P<0.001). Mean arterial blood pressure was reduced with betaxolol and timolol by 4.7±7.1 mmHg (P<0.03), and 3.2±5.6 mmHg (P<0.05), respectively, but the difference between two groups was not significant. Pulse rate was reduced with timolol and betaxolol by 8 ±3.4 beats/min, and 6.5±5.6 beats/min, respectively (P<0.01), with no significant difference between two groups. Mean reduction in basic tear secretion with timolol and betaxolol was 0.8±2.1 mm/5min (P<0.2), and 0.5±1.9 mm/5min (p<0.3), respectively; intergroup comparison was also not significant. Patients in 85.7% of the betaxolol group and 35.7% of the timolol group complained of eye burning (P<0.01). Other symptoms were similar between two groups.Conclusion: Timolol is superior to betaxolol in treatment of early glaucoma or ocular hypertension, but both drugs should be used with caution in patients with cardiovascular compromise.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

MOHAMMAD RABI, H., RAJAVI, ZH., & RAHMATI KAMEL, M.. (2002). A COMPARISON OF OCULAR HYPOTENSIVE RESPONSE TO BETAXOLOL AND TIMOLOL . BINA, 7(3), 236-245. SID. https://sid.ir/paper/528202/en

Vancouver: Copy

MOHAMMAD RABI H., RAJAVI ZH., RAHMATI KAMEL M.. A COMPARISON OF OCULAR HYPOTENSIVE RESPONSE TO BETAXOLOL AND TIMOLOL . BINA[Internet]. 2002;7(3):236-245. Available from: https://sid.ir/paper/528202/en

IEEE: Copy

H. MOHAMMAD RABI, ZH. RAJAVI, and M. RAHMATI KAMEL, “A COMPARISON OF OCULAR HYPOTENSIVE RESPONSE TO BETAXOLOL AND TIMOLOL ,” BINA, vol. 7, no. 3, pp. 236–245, 2002, [Online]. Available: https://sid.ir/paper/528202/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops