TNFRSF13B/TACI ALTERATIONS IN TURKISH PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY AND IGA DEFICIENCY

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KARACA NESLIHAN EDEER; SEVERCAN EZGI ULUSOY; GUVEN BURCU; AZARSIZ ELIF; AKSU GUZIDE; KUTUKCULER NECIL

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Journal: Avicenna Journal of Medical Biotechnology Year:2018 | Volume:10 | Issue:3 Page(s): 192-195

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Title

TNFRSF13B/TACI ALTERATIONS IN TURKISH PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY AND IGA DEFICIENCY

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Keywords

COMMON VARIABLE IMMUNODEFICIENCY

IGA DEFICIENCY

TACI

MUTATION

RESPIRATORY TRACT INFECTION

Abstract

Background: The Transmembrane Activator and Calcium modulator ligand Interactor (TACI), encoded byTNFRSF13B/TACI gene, is mutated in some patients with COMMON VARIABLE IMMUNODEFICIENCY (CVID) and IGA DEFICIENCY (IgAD). The purpose of the study was to investigate for the first time in Turkish patients the prevalence of TNFRSF13Balterations in CVID, selective and partial IgAD patients.Methods: Forty two CVID, 36 selective IgAD, 34 partial IgAD and 25 healthy controls were included. All patients were examined forTNFRSF13B gene MUTATIONs by PCR.Results: The percentages of TNFRSF13B MUTATIONs in CVID, selective and partial IgAD patients were 7.1, 2.7 and 2.9%, respectively. No disease causingTNFRSF13B MUTATION in healthy controls was found. Patients with TACI MUTATIONs had recurrent RESPIRATORY TRACT INFECTIONs. None of them experienced autoimmunity, bronchiectasis or granulomatous disease. In conclusion, TNFRSF13B MUTATIONs were present not only in CVID patients, but also in IgAD cases.Conclusion: Modifier genes as well as their combination with other genetic or environmental factors may play an important role in the development of the immunodeficiency phenotype.

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APA: Copy

KARACA, NESLIHAN EDEER, SEVERCAN, EZGI ULUSOY, GUVEN, BURCU, AZARSIZ, ELIF, AKSU, GUZIDE, & KUTUKCULER, NECIL. (2018). TNFRSF13B/TACI ALTERATIONS IN TURKISH PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY AND IGA DEFICIENCY. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 10(3), 192-195. SID. https://sid.ir/paper/313954/en

Vancouver: Copy

KARACA NESLIHAN EDEER, SEVERCAN EZGI ULUSOY, GUVEN BURCU, AZARSIZ ELIF, AKSU GUZIDE, KUTUKCULER NECIL. TNFRSF13B/TACI ALTERATIONS IN TURKISH PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY AND IGA DEFICIENCY. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2018;10(3):192-195. Available from: https://sid.ir/paper/313954/en

IEEE: Copy

NESLIHAN EDEER KARACA, EZGI ULUSOY SEVERCAN, BURCU GUVEN, ELIF AZARSIZ, GUZIDE AKSU, and NECIL KUTUKCULER, “TNFRSF13B/TACI ALTERATIONS IN TURKISH PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY AND IGA DEFICIENCY,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 10, no. 3, pp. 192–195, 2018, [Online]. Available: https://sid.ir/paper/313954/en

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