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Information Journal Paper

Title

LACK OF ASSOCIATION BETWEEN INTERLEUKIN 12 C(-1188)A POLYMORPHISM AND IRRITABLE BOWEL SYNDROME

Pages

  35-48

Abstract

 Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder, characterized by recurrent abdominal pain and altered bowel habits. This study was performed to investigate the important role of INTERLEUKIN-12 (IL-12) in intestinal inflammation. For this study seventy one patients with IBS and 140 controls were investigated. The allele and genotype frequencies of IL-12 C (-1188) A were determined using polymerase chain reaction with sequence-specific primers. The allele A was more common that the allele C in both groups of patients and controls. There was not any significant difference on IL-12 alleles and genotypes between patients and controls. The AA genotype was the most common genotypes, which was seen in 57.4% of the patients and 51.4% of the controls (p=0.53). Although frequency of the CC genotype in the control group was lower than the patient group, this difference was not significant (5.7% vs.11.5%, respectively, p=0.16). Considering the lack of association between IL-12 C (-1188) A polymorphism and IBS, this cytokine gene polymorphism may not have significant role in the pathophysiology of disease.

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    APA: Copy

    BARKHORDARI, ELHAM, AMIRZARGAR, ALI AKBAR, EBRAHIMI DARYANI, NASER, MAHMOUDI, MAHDI, ANSARIPOUR, BITA, ALIGHARDASHI, MARYAM, AHMADI ASHTIANI, HAMID REZA, BASHASHATI, MOHAMMAD, & REZAEI, NIMA. (2011). LACK OF ASSOCIATION BETWEEN INTERLEUKIN 12 C(-1188)A POLYMORPHISM AND IRRITABLE BOWEL SYNDROME. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 3(1 (8)), 35-48. SID. https://sid.ir/paper/313745/en

    Vancouver: Copy

    BARKHORDARI ELHAM, AMIRZARGAR ALI AKBAR, EBRAHIMI DARYANI NASER, MAHMOUDI MAHDI, ANSARIPOUR BITA, ALIGHARDASHI MARYAM, AHMADI ASHTIANI HAMID REZA, BASHASHATI MOHAMMAD, REZAEI NIMA. LACK OF ASSOCIATION BETWEEN INTERLEUKIN 12 C(-1188)A POLYMORPHISM AND IRRITABLE BOWEL SYNDROME. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2011;3(1 (8)):35-48. Available from: https://sid.ir/paper/313745/en

    IEEE: Copy

    ELHAM BARKHORDARI, ALI AKBAR AMIRZARGAR, NASER EBRAHIMI DARYANI, MAHDI MAHMOUDI, BITA ANSARIPOUR, MARYAM ALIGHARDASHI, HAMID REZA AHMADI ASHTIANI, MOHAMMAD BASHASHATI, and NIMA REZAEI, “LACK OF ASSOCIATION BETWEEN INTERLEUKIN 12 C(-1188)A POLYMORPHISM AND IRRITABLE BOWEL SYNDROME,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 3, no. 1 (8), pp. 35–48, 2011, [Online]. Available: https://sid.ir/paper/313745/en

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