EFFECT OF EXTRACELLULAR CALCIUM DEPLETION ON ATRIAL NATRIURETIC FACTOR SECRETION AND GENE EXPRESSION

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IMEN SHAHIDI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES Year:2006 | Volume:2 | Issue:1 Page(s): 23-30

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Title

EFFECT OF EXTRACELLULAR CALCIUM DEPLETION ON ATRIAL NATRIURETIC FACTOR SECRETION AND GENE EXPRESSION

Author(s)

IMEN SHAHIDI M. | Issue Writer Certificate

Keywords

ATRIAL NATRIURETIC FACTOR

EXTRACELLULAR CALCIUM

GENE EXPRESSION

Abstract

Extracellular Ca2+ concentration ([Ca2+]o) may be one of the factors affecting atrial natriuretic factor (ANF) release. In the previous studies, there are opposite reports about the effect of [Ca2+]o on ANF secretion. Therefore, the effect of [Ca2+]o depletion on ANF secretion and gene expression was studied in the present research. Isolated right atria from rats were perfused for 6 and 2 hours in the presence and absence of [Ca2+]o, and ANF secretion were measured using radioimmunoassay method. Cyclohexamide was used in another group as a protein synthesis inhibitor. ANF mRNA level in atria measured by Real time PCR. [Ca2+]o depletion induced a significant increase in basal ANF release. This stimulatory effect peaked at 2 h, then started to decrease and reached around basal levels by 6 h. Protein synthesis inhibition by cyclohexamide did not abolish or significantly decrease the stimulatory effect of Ca2+-free media on ANF secretion. The ANF gene expression was not significantly affected by Ca2+-free media. These results suggest that the contractile and endocrine function of atrial cardiocytes are differently affected by [Ca2+]o and may represent an adaptation to the dual roles of the atrial myocytes contraction and secretion.

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APA: Copy

IMEN SHAHIDI, M.. (2006). EFFECT OF EXTRACELLULAR CALCIUM DEPLETION ON ATRIAL NATRIURETIC FACTOR SECRETION AND GENE EXPRESSION. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2(1), 23-30. SID. https://sid.ir/paper/300147/en

Vancouver: Copy

IMEN SHAHIDI M.. EFFECT OF EXTRACELLULAR CALCIUM DEPLETION ON ATRIAL NATRIURETIC FACTOR SECRETION AND GENE EXPRESSION. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2006;2(1):23-30. Available from: https://sid.ir/paper/300147/en

IEEE: Copy

M. IMEN SHAHIDI, “EFFECT OF EXTRACELLULAR CALCIUM DEPLETION ON ATRIAL NATRIURETIC FACTOR SECRETION AND GENE EXPRESSION,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 2, no. 1, pp. 23–30, 2006, [Online]. Available: https://sid.ir/paper/300147/en

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