EFFECTS OF CHOLECYSTOKININ RECEPTOR ANTAGONISTS ON MORPHINE- AND COCAINEINDUCED HYPOTHERMIA

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REZAYAT M.; GHAZI KHANSARI M.; MOUSTAFAVI MEHR M.; ZARINDAST M.R.

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Paper Information

Journal: MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN Year:2000 | Volume:14 | Issue:2 Page(s): 151-154

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Title

EFFECTS OF CHOLECYSTOKININ RECEPTOR ANTAGONISTS ON MORPHINE- AND COCAINEINDUCED HYPOTHERMIA

Author(s)

REZAYAT M. | GHAZI KHANSARI M. | MOUSTAFAVI MEHR M. | ZARINDAST M.R.

Keywords

CCK ANTAGONISTS

COCAINE

MORPHINE

HYPOTHERMIA

MICE

Abstract

The effects of cholecystokinin (CCK) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. In the present work, subcutaneous (SC) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. Administration of CCKA receptor antagonist MK-329 (0.5-1.5 mg/kg), CCKB receptor antagonist L-365, 260 (0.5-1.5 mg/kg) and CCK receptor antagonist proglumide (15-45 mg/kg) 60 min. prior to cocaine injection reduced hypothermia induced by cocaine. MK-329 or proglumide also reduced the morphine response. Single administration of MK-329 and L-365, 260 to mice decreased mice core body temperature. It is concluded that the hypothermic effect of cocaine and morphine may be mediated through CCKA and CCKB receptor mechanism(s).

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APA: Copy

REZAYAT, M., GHAZI KHANSARI, M., MOUSTAFAVI MEHR, M., & ZARINDAST, M.R.. (2000). EFFECTS OF CHOLECYSTOKININ RECEPTOR ANTAGONISTS ON MORPHINE- AND COCAINEINDUCED HYPOTHERMIA. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 14(2), 151-154. SID. https://sid.ir/paper/294287/en

Vancouver: Copy

REZAYAT M., GHAZI KHANSARI M., MOUSTAFAVI MEHR M., ZARINDAST M.R.. EFFECTS OF CHOLECYSTOKININ RECEPTOR ANTAGONISTS ON MORPHINE- AND COCAINEINDUCED HYPOTHERMIA. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2000;14(2):151-154. Available from: https://sid.ir/paper/294287/en

IEEE: Copy

M. REZAYAT, M. GHAZI KHANSARI, M. MOUSTAFAVI MEHR, and M.R. ZARINDAST, “EFFECTS OF CHOLECYSTOKININ RECEPTOR ANTAGONISTS ON MORPHINE- AND COCAINEINDUCED HYPOTHERMIA,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 14, no. 2, pp. 151–154, 2000, [Online]. Available: https://sid.ir/paper/294287/en

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