SYNTHESIS OF SOME NEW TETRAHYDROPYRIMIDINE DERIVATIVES AS POSSIBLE ANTIBACTERIAL AGENTS

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FOROUGHIFAR NASER; KARIMI BEROMI SOMAYEH; PASDAR HODA; Shahi Masoomeh

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Paper Information

Journal: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH Year:2017 | Volume:16 | Issue:2 Page(s): 596-601

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Title

SYNTHESIS OF SOME NEW TETRAHYDROPYRIMIDINE DERIVATIVES AS POSSIBLE ANTIBACTERIAL AGENTS

Author(s)

FOROUGHIFAR NASER | KARIMI BEROMI SOMAYEH | PASDAR HODA | Shahi Masoomeh | Issue Writer Certificate

Keywords

TETRAHYDROPYRIMIDINE

ANTIMICROBIAL ACTIVITY

BIGINELLI REACTION

Abstract

Heterocyclic compounds containing a pyrimidine nucleus are of special interests thanks to their applications in medicinal chemistry as they are the basic skeleton of several bioactive compounds such as antifungal, antibacterial, antitumor and antitubercular. As a part of our research in the synthesis of pyrimidine derivatives containing biological activities, some new tetrahydropyrimidine derivatives (1-10) were synthesized via Biginelli reaction using HCl or DABCO as a catalyst with good yields. All structures of products were confirmed by IR, 1H NMR and 13C NMR spectroscopy. The antibacterial activity of some synthesized compounds was investigated against Staphylococcus aureus (ATCC 6538), Staphylococcus epidermidis (ATCC 12228), Bacillus cereus (ATCC14579), Esherichia coli (ATCC 25922), Klebsiella pneumonia (ATCC 13883) and Pseudomonas aeruginosa (PAO1) bacteria. Some of these compounds such as 8 and 10 exhibited a good to significant antibacterial activity.

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APA: Copy

FOROUGHIFAR, NASER, KARIMI BEROMI, SOMAYEH, PASDAR, HODA, & Shahi, Masoomeh. (2017). SYNTHESIS OF SOME NEW TETRAHYDROPYRIMIDINE DERIVATIVES AS POSSIBLE ANTIBACTERIAL AGENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(2), 596-601. SID. https://sid.ir/paper/288924/en

Vancouver: Copy

FOROUGHIFAR NASER, KARIMI BEROMI SOMAYEH, PASDAR HODA, Shahi Masoomeh. SYNTHESIS OF SOME NEW TETRAHYDROPYRIMIDINE DERIVATIVES AS POSSIBLE ANTIBACTERIAL AGENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(2):596-601. Available from: https://sid.ir/paper/288924/en

IEEE: Copy

NASER FOROUGHIFAR, SOMAYEH KARIMI BEROMI, HODA PASDAR, and Masoomeh Shahi, “SYNTHESIS OF SOME NEW TETRAHYDROPYRIMIDINE DERIVATIVES AS POSSIBLE ANTIBACTERIAL AGENTS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 2, pp. 596–601, 2017, [Online]. Available: https://sid.ir/paper/288924/en

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