QUANTITATIVE DETERMINATION OF THREE ANGIOTENSIN-II-RECEPTOR ANTAGONISTS IN PRESENCE OF HYDROCHLOROTHIAZIDE BY RP-HPLC IN THEIR TABLET PREPARATIONS

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HAFEZ HANY MOHAMMED; ELSHANAWANE ABDULLAH AHMED; ABDELAZIZ LOBNA MOHAMMED; KAMAL MAGDA MOHAMMED

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Paper Information

Journal: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH Year:2013 | Volume:12 | Issue:4 Page(s): 635-643

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Title

QUANTITATIVE DETERMINATION OF THREE ANGIOTENSIN-II-RECEPTOR ANTAGONISTS IN PRESENCE OF HYDROCHLOROTHIAZIDE BY RP-HPLC IN THEIR TABLET PREPARATIONS

Author(s)

HAFEZ HANY MOHAMMED | ELSHANAWANE ABDULLAH AHMED | ABDELAZIZ LOBNA MOHAMMED | KAMAL MAGDA MOHAMMED | Issue Writer Certificate

Keywords

RP-HPLC

ANGIOTENSIN-II-RECEPTOR

HYDROCHLOROTHIAZIDE

Abstract

Losartan potassium, Valsartan, Telmisartan and Irbesartan are angiotensin-II-receptor antagonists (ARA II) group which used in treatment of hypertension alone or in combination with other drugs mainly Hydrochlorothiazide. RP- HPLC method was developed for the assay of three angiotensin-II-receptor antagonists (ARA-IIs) in presence of Hydrochlorothiazide. The method was performed by reversed phase high performance liquid chromatography using a mobile phase which is consisted of 0.025 M potassium dihydrogen phosphate (pH 6.0): acetonitrile=65: 35% with detection at 220 nm on an ACE C18 column (250 mm×4.6 mm, 5 mm) at flow rate 1.5 mL/min in an isocratic manner. The proposed method was validated according to ICH guidline in terms of linearity, accuracy, precision, robustness, limit of detection and limit of quantitation.

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APA: Copy

HAFEZ, HANY MOHAMMED, ELSHANAWANE, ABDULLAH AHMED, ABDELAZIZ, LOBNA MOHAMMED, & KAMAL, MAGDA MOHAMMED. (2013). QUANTITATIVE DETERMINATION OF THREE ANGIOTENSIN-II-RECEPTOR ANTAGONISTS IN PRESENCE OF HYDROCHLOROTHIAZIDE BY RP-HPLC IN THEIR TABLET PREPARATIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(4), 635-643. SID. https://sid.ir/paper/288184/en

Vancouver: Copy

HAFEZ HANY MOHAMMED, ELSHANAWANE ABDULLAH AHMED, ABDELAZIZ LOBNA MOHAMMED, KAMAL MAGDA MOHAMMED. QUANTITATIVE DETERMINATION OF THREE ANGIOTENSIN-II-RECEPTOR ANTAGONISTS IN PRESENCE OF HYDROCHLOROTHIAZIDE BY RP-HPLC IN THEIR TABLET PREPARATIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(4):635-643. Available from: https://sid.ir/paper/288184/en

IEEE: Copy

HANY MOHAMMED HAFEZ, ABDULLAH AHMED ELSHANAWANE, LOBNA MOHAMMED ABDELAZIZ, and MAGDA MOHAMMED KAMAL, “QUANTITATIVE DETERMINATION OF THREE ANGIOTENSIN-II-RECEPTOR ANTAGONISTS IN PRESENCE OF HYDROCHLOROTHIAZIDE BY RP-HPLC IN THEIR TABLET PREPARATIONS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 4, pp. 635–643, 2013, [Online]. Available: https://sid.ir/paper/288184/en

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