COMPARATIVE ANALYSIS OF CD4+ AND CD8+ T CELLS IN TUMOR TISSUES, LYMPH NODES AND THE PERIPHERAL BLOOD FROM PATIENTS WITH BREAST CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RIAZI RAD FARHAD; AJDARY SOHEILA; OMRANIPOUR RAMESH; ALIMOHAMMADIAN MOHAMMAD HOSSEIN; HASSAN ZAHIR M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN BIOMEDICAL JOURNAL Year:2015 | Volume:19 | Issue:1 Page(s): 35-44

Download Full-Text

View:

355

Download:

183

Cites:

Information Journal Paper

Title

COMPARATIVE ANALYSIS OF CD4+ AND CD8+ T CELLS IN TUMOR TISSUES, LYMPH NODES AND THE PERIPHERAL BLOOD FROM PATIENTS WITH BREAST CANCER

Author(s)

Keywords

BREAST NEOPLASMS

CD4+ T LYMPHOCYTE

CD8+ T LYMPHOCYTES

CXCL10

GRANZYMES

Abstract

Background: CD4+and CD8+T cells are the main types of lymphocytes in cell-mediated immunity and play a central role in the induction of efficient immune responses against tumors. The frequencies of T cell subtypes in the peripheral blood and tumor tissues, and draining lymph nodes (dLN) can be considered as useful markers for evaluation of the immune system in cancers.Methods: In this study, the frequencies of CD4+and CD8+T cells in blood, tumor tissues, and dLN samples of breast cancer patients were compared with each other and with similar tissues from normal individuals. Immunophenotyping was carried out by flow cytometry and the expression levels of CXCL10, granzyme B, and mammaglobin were evaluated by real-time PCR.Results: In the peripheral blood, there were no differences in the T cell subsets between the patients and the normal individuals. The frequency of CD8+T cells was significantly higher in tumor tissue than normal breast tissues while granzyme B expression was similar. Based on mammaglobin expression levels, dLN have been classified into micro- and macro-metastatic dLN. We found significantly lower frequency of CD4+in macro-metastatic dLN than micro-metastatic dLN. CD8+ frequency was similar in both dLN; however, granzyme B expression was higher in micro-metastatic ones. There was not any significant difference in CXCL10 expression between the two types of dLN.Conclusion: Based on our results, although the tumor does not affect the systemic immunity, tumoral cells affect the local immune system in the tumoral tissues and the metastatic dLN.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

RIAZI RAD, FARHAD, AJDARY, SOHEILA, OMRANIPOUR, RAMESH, ALIMOHAMMADIAN, MOHAMMAD HOSSEIN, & HASSAN, ZAHIR M.. (2015). COMPARATIVE ANALYSIS OF CD4+ AND CD8+ T CELLS IN TUMOR TISSUES, LYMPH NODES AND THE PERIPHERAL BLOOD FROM PATIENTS WITH BREAST CANCER. IRANIAN BIOMEDICAL JOURNAL, 19(1), 35-44. SID. https://sid.ir/paper/277388/en

Vancouver: Copy

RIAZI RAD FARHAD, AJDARY SOHEILA, OMRANIPOUR RAMESH, ALIMOHAMMADIAN MOHAMMAD HOSSEIN, HASSAN ZAHIR M.. COMPARATIVE ANALYSIS OF CD4+ AND CD8+ T CELLS IN TUMOR TISSUES, LYMPH NODES AND THE PERIPHERAL BLOOD FROM PATIENTS WITH BREAST CANCER. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(1):35-44. Available from: https://sid.ir/paper/277388/en

IEEE: Copy

FARHAD RIAZI RAD, SOHEILA AJDARY, RAMESH OMRANIPOUR, MOHAMMAD HOSSEIN ALIMOHAMMADIAN, and ZAHIR M. HASSAN, “COMPARATIVE ANALYSIS OF CD4+ AND CD8+ T CELLS IN TUMOR TISSUES, LYMPH NODES AND THE PERIPHERAL BLOOD FROM PATIENTS WITH BREAST CANCER,” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 1, pp. 35–44, 2015, [Online]. Available: https://sid.ir/paper/277388/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops