مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

25
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

51
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

Citicoline for Traumatic Brain Injuries: A Systematic Review and Implications for Future Research

Pages

  140-149

Abstract

 Background and Objectives: Traumatic brain injury (TBI) is a catastrophic condition that exerts a high burden on individuals, families, and societies. The objective of this study was to systematically review the human studies on the efficacy and safety of citicoline for the management of TBIs. Materials and Methods: Relevant articles were identifi, ed by searching PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials on July 1, 2022. Results: Eighteen studies met the predefined eligibility criteria, including 12 randomized controlled trials (RCTs). Citicoline was administered via injectional (n = 11, 61. 1%), enteral (n = 5, 27. 8%), both injectional and enteral (n = 1, 5. 5%), and unknown (n = 1, 5. 5%) routes. Numerically, studies reporting the favorable impact of citicoline on patient outcome outnumbered (n = 13, 72. 2%). However, the largest RCT could not demonstrate positive results. Only two studies reported complications, and the observed difference between citicoline and placebo groups was not statistically significant in either of them. Conclusion: Despite promising results in animal studies, human studies have shown inconsistent results regarding the role of citicoline in TBI management. Homogeneity of patients, subgroups of patients who might benefit more, the efficacy of citicoline as a part of combination therapies, and factors that could potentially influence the pharmacokinetics and brain uptake of citicoline should be considered when designing future studies.

Multimedia

  • No record.

    • Cites

    References

    Cite

    APA: Copy

    KHORMALI, MOEIN, MOHAMMADI, FATEMEH, Amouzade, Maede, Baigi, Vali, & SHARIF ALHOSEINI, MAHDI. (2022). Citicoline for Traumatic Brain Injuries: A Systematic Review and Implications for Future Research. ARCHIVES OF TRAUMA RESEARCH, 11(3), 140-149. SID. https://sid.ir/paper/1082347/en

    Vancouver: Copy

    KHORMALI MOEIN, MOHAMMADI FATEMEH, Amouzade Maede, Baigi Vali, SHARIF ALHOSEINI MAHDI. Citicoline for Traumatic Brain Injuries: A Systematic Review and Implications for Future Research. ARCHIVES OF TRAUMA RESEARCH[Internet]. 2022;11(3):140-149. Available from: https://sid.ir/paper/1082347/en

    IEEE: Copy

    MOEIN KHORMALI, FATEMEH MOHAMMADI, Maede Amouzade, Vali Baigi, and MAHDI SHARIF ALHOSEINI, “Citicoline for Traumatic Brain Injuries: A Systematic Review and Implications for Future Research,” ARCHIVES OF TRAUMA RESEARCH, vol. 11, no. 3, pp. 140–149, 2022, [Online]. Available: https://sid.ir/paper/1082347/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button