Brain Atrophy and Physical and Cognitive Disability in Multiple Sclerosis

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Casanova Peno Luis Ignacio; De Silanes De Miguel Carlos Lopez; de Torres Laura; Eimil Ortiz Miriam; Jose Gil Moreno Maria; Oyanguren Rodeno Beatriz; Terrero Carpio Rodrigo; Sabín Munoz Julia; Patricia Díaz Montoya Blanca; Angel Saiz Sepulveda Miguel; De Antonio Sanz Esther; Abellan Ayuso Sara; Gonzalez Salaices Marta

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Journal: BASIC AND CLINICAL NEUROSCIENCE Year:2023 | Volume:14 | Issue:2 Page(s): 311-316

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Title

Brain Atrophy and Physical and Cognitive Disability in Multiple Sclerosis

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Keywords

Brain atrophy

Cognitive dysfunction

Multiple sclerosis

Disease progression

Magnetic resonance imaging

Abstract

Introduction: Brain atrophy is associated with physical disability in multiple sclerosis (MS), but there is a great variability between different studies and methodologies, and its use is still limited to research projects. We aimed to analyze the relationship between several volumetric measurements and physical disability and cognitive functioning in MS patients in a clinical practice setting. Methods: This is a cross-sectional study. A total of 41 patients (31 relapsing-remitting MS, 6 secondary-progressive MS, and 4 primary-progressive MS) were included. Whole brain volume (WBV), gray matter volume (GMV), and T2 lesion load (T2L) were obtained using Icometrix®,software. Physical disability was measured with the Expanded Disability Status Scale (EDSS), and cognitive status was evaluated with the brief repeatable battery of neuropsychological tests (BRB-N). The relationship between brain volumes and EDSS was analyzed through linear multivariate regression. The association between volumetry measurements and the number of affected cognitive domains was studied with negative binomial regression. Results: GMV was associated with age (b=-1. 7, P=0. 014) and with EDSS (b=-7. 55, P=0. 013). T2L was associated with EDSS (b=2. 29, P=0. 032). The number of affected cognitive domains was associated with clinical phenotype, worse in primary progressive MS (PPMS). There was not correlations between cognitive impairment and cerebral volumes. Conclusion: Brain atrophy measurement is feasible in clinical practice setting, and it is helpful in monitoring the EDSS progression. Primary progressive phenotype is associated with greater risk of cognitive dysfunction.

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APA: Copy

Casanova Peno, Luis Ignacio, De Silanes De Miguel, Carlos Lopez, de Torres, Laura, Eimil Ortiz, Miriam, Jose Gil Moreno, Maria, Oyanguren Rodeno, Beatriz, Terrero Carpio, Rodrigo, Sabín Munoz, Julia, Patricia Díaz Montoya, Blanca, Angel Saiz Sepulveda, Miguel, De Antonio Sanz, Esther, Abellan Ayuso, Sara, & Gonzalez Salaices, Marta. (2023). Brain Atrophy and Physical and Cognitive Disability in Multiple Sclerosis. BASIC AND CLINICAL NEUROSCIENCE, 14(2), 311-316. SID. https://sid.ir/paper/1070481/en

Vancouver: Copy

Casanova Peno Luis Ignacio, De Silanes De Miguel Carlos Lopez, de Torres Laura, Eimil Ortiz Miriam, Jose Gil Moreno Maria, Oyanguren Rodeno Beatriz, Terrero Carpio Rodrigo, Sabín Munoz Julia, Patricia Díaz Montoya Blanca, Angel Saiz Sepulveda Miguel, De Antonio Sanz Esther, Abellan Ayuso Sara, Gonzalez Salaices Marta. Brain Atrophy and Physical and Cognitive Disability in Multiple Sclerosis. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2023;14(2):311-316. Available from: https://sid.ir/paper/1070481/en

IEEE: Copy

Luis Ignacio Casanova Peno, Carlos Lopez De Silanes De Miguel, Laura de Torres, Miriam Eimil Ortiz, Maria Jose Gil Moreno, Beatriz Oyanguren Rodeno, Rodrigo Terrero Carpio, Julia Sabín Munoz, Blanca Patricia Díaz Montoya, Miguel Angel Saiz Sepulveda, Esther De Antonio Sanz, Sara Abellan Ayuso, and Marta Gonzalez Salaices, “Brain Atrophy and Physical and Cognitive Disability in Multiple Sclerosis,” BASIC AND CLINICAL NEUROSCIENCE, vol. 14, no. 2, pp. 311–316, 2023, [Online]. Available: https://sid.ir/paper/1070481/en

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