Background: Stroke rehabilitation is a crucial phase for recovery, focusing on improving physical function and independence. Nurse-led support programs have shown promise in aiding stroke survivors during rehabilitation, enhancing physical activity and functional outcomes. This review aims to examine the impact of nurse-led support programs on rehabilitation and physical activity in stroke patients. Methods: A systematic review and meta-analysis of randomized controlled trials published from 2019 onwards were conducted, focusing on nurse-led interventions for stroke survivors. A comprehensive literature search was performed across multiple databases, selecting studies based on quality criteria. Eight studies were included, evaluating intervention duration, patient demographics, types of stroke (Transient ischemic attack and Acute ischemic stroke), and outcomes related to rehabilitation and physical activity. Meta-analysis was performed using statistical software, calculating effect sizes as mean differences and assessing heterogeneity using a standard statistical test. Results: The meta-analysis demonstrated that nurse-led interventions significantly improved rehabilitation (mean difference = 6. 23, 95% confidence interval 2. 05-10. 40, P<0. 001) and physical activity (mean difference = 11. 03, 95% confidence interval 4. 88-26. 95, P<0. 001). Subgroup analysis indicated greater effectiveness in rehabilitation for interventions lasting less than 3 months compared to those longer than 3 months. Conclusions: Nurse-led support programs have a significant positive impact on rehabilitation and physical activity in stroke patients. Structured, individualized exercise plans and continuous support are key in enhancing patients' physical activity levels and functional mobility, essential for successful rehabilitation.