Background and Objectives: Consumable fats in ruminant products are the main source of various conjugated linoleic acid isomers with a wide range of positive effects on human health. The biological role of various isomers of conjugated linoleic acid and some precursor compounds such as rumenic acid and vaccenic acid have been extensively studied. Various genetic factors such as race type are considered as effective factors on the effect of different environmental factors on plasma levels, growth, energy distribution between different tissues of the body, and the pattern of fatty acids and the chemical composition of the carcass. There are several studies on dairy cows on the role of various dietary factors including fatty acids in their effect on performance and energy metabolism. However, much research has been done in this field even in Iran and there is no comparison between the tailed and no-tailed sheep in the type of response to different sources of dietary energy. Therefore, this study was performed to evaluate the effect of high-energy diets rich in carbohydrates or protected fat sources on dry matter intake, weight gain, expression of the TNF-α,gene, and some blood metabolites in male lambs of Taleshi and Zel. Materials and Methods: This study was performed in an experimental period of 116 days (14 days of habituation and 102 days of sampling). At the end of the habituation period before breakfast, the animals were weighed and kept individually (6 lambs of Taleshi breed and 6 lambs of Zel breed for each treatment). The control diet (fat-free diet), a diet containing 4% saturated fat supplement rich in stearic acid, and a diet containing 4% unsaturated fat supplement protected apparent digestibility of dry matter, organic matter, crude fat, crude protein, and insoluble fibers in neutral detergent and insoluble fibers in acid detergent was measured by the recommended method. The amount of dry matter consumed was measured by taking into account the amount of dry matter remaining in the manager (post-manager) and the amount of dry matter in the diet. To measure weight changes, lambs were weighed every two weeks before feeding until the end of the experiment using a digital calibrator. Blood samples were taken from the lambs intravenously every two weeks until the end of the experimental period, four hours after the morning meal. TNF-α,gene expression was measured in the Rasta laboratory located in West Azerbaijan Science and Technology Park. Results: The highest level of feed intake at the end of the period belonged to Zel and Taleshi lambs that consumed the feed containing saturated stearic fatty acid. The digestibility of dry matter, organic matter, NDF, and ADF was affected by fat source, However, the effect of race and the interaction between race and type of fat did not affect their digestibility. The interaction effect of race and fat on the digestibility of crude protein and ether extract was significant (P<0. 05). Crude protein digestibility was not affected by the fat type. The highest digestibility of crude protein was observed in the treatment of protected unsaturated fat of Taleshi breed and the lowest amount was observed in the treatment of protected unsaturated fat of Zel. The highest digestibility of ether extract was observed in the treatment of Taleshi protected unsaturated fat (P<0. 05). The expression of the TNF-α,gene was higher in the subcutaneous fat of the protected lambs of the unsaturated treatment (P<0. 05). Also, the TNF-α,gene expression was higher in tail fat and tail fat samples of talus lambs with protective unsaturated treatment and less stearic acid treatment in Zell lambs than in other treatments (<0. 05). Blood triglycerides of Zel and Taleshi fattening lambs were subjected to the interaction of treatment factors over time, treatment in the race, and triple interaction of race over time treatment during the 16-week fattening period. Conclusion: In general, it can be concluded that the addition of fat supplements in the diet of Taleshi and Zel lambs improves blood parameters and thus improves performance (weight gain and feed intake). Since the best results were obtained in the treatment of protected unsaturated fat supplement, the use of this fat supplement at the level of 4% is recommended in Taleshi and Zel lambs' nutrition.