Adrenal tumors that secrete androgens are rare; the tumor may be an adenoma or a carcinoma. This paper discusses the signs and symptoms, diagnostic methods, treatment and prognosis of these tumors, witnessed in 3 cases of androgen producing adrenal tumors. The first case was a 14 year old girl presented with hirsutism and virilism and primary amenorrhea. Testosterone and DHEAS showed very high levels while other adrenal hormones were within in normal limits. A pure androgen producing adrenal adenoma was diagnosed in this patient. The second case was a 7 year old girl with hirsutism, virilism and cushingoid facial features, acne and weight gain and a large abdominal mass. An adrenal carcinoma producing cortisol, testosterone, and DHEAS was diagnosed in this patient. The third case was a 10 month old baby with weight gain cushingoid facial features, acne and growth of pubic hair. High level of DHEAS, testosterone and cortisol due to an adrenocortical carcinoma, detected in this patient.

Introduction: The majority of drugs act through binding with target proteins. Prediction of the interaction between small molecules and proteins is a key element in the process of drug discovery.Advances in Structural Genomics have provided this possibility to access three-dimensional structures of the proteins which are targeted by drugs. Since laboratory processes through which drug-target protein interactions are investigated require high cost and energy, in silico methods can be used as effective strategies for providing useful information in support of experimental methods.Methods: In this study, the interaction between androgen receptor and Bicalutamide, a widely used drug in the treatment of prostate cancer, was investigated via computational analyses. The docking analysis of this receptor with Bicalutamide was done using Autodock4.2.6 and analysis of complexes was done through LigPlot4.5.3 and Chimera1.5.3.Results: The obtained results showed that amino acid residues Met-895, Trp-741, Arg-752, Ile-899, Leu-707, Gly-708, Gln-711, Met-745, Met-749, Thr-87, Phe-764, and Met-749 (through forming hydrophobic bonds with the drug) and amino acid residues Asn-705 and Leu-704 (through forming hydrogen bonds with the drug) play a significant role in the protein-drug interaction and cause proper positioning of the drug in protein and consequently its efficacy.Conclusion: These results could be used in the future studies for investigation of drug resistance to Bicalutamide and to develop more efficient medicines.

Introduction: The effects of environmental exposure during critical periods of gestational life on fetal growth and development have been confirmed by a large number of studies on human and animal models. Sex hormons are among the most influential environmental factor which affect on growth and development of different organs of fetus. Among them, androgens are the most important ones because they have various sources of production and secretion. Result previous studies that exposure to androgens during pregnancy may act as a teratogenic agent and cause defects, deministrated in offspring's endocrine and neural system developments. Considering the importance of this critical period for the development of some abnormal features in adulthood, basic research and clinical prevention efforts need to be run at this stage. This review article presents evidence on the effect of excessive androgens during fetal life on embryo development and evolution, which can lead to the development of certain phenotypes / diseases in adulthood.

Nowadays, with the increased prevalence of depression in the societies, researchers have focused more attention on the long term effects of antidepressant medications on reproduction and sexual function. In vitro studies have shown that tricyclic antidepressants such as imipramine and nortriptyline impair sperm motility. Also, Serotonergic antidepressants such as fluoxetine and venlafaxine reduce male reproduction indirectly via effects on sexual desire (libido), erection and ejaculatory ability. Mechanisms of antidepressants are still unknown for changes in sperm function. Only neuroendocrine factors regulating the activity of the chemical mediators may have an effective role in the male sexual function. Most of the chemical mediators affect on hypothalamichypophyseal- gonadal axis and influence the spermatogenesis in men by this way. They can affect sexual arousal, erection, ejaculation and orgasm by sympathetic and parasympathetic regulation control and may influence fertility by their side effects on cholinergic and adrenergic receptors. In this review, the relationship between antidepressant medications and male reproduction, effects of antidepressant medications on the male sexual function and androgens levels will be discussed.

Preeclampsia is a major cause of morbidity and mortality during pregnancy. Although the pathophysiology of preeciampsia has not yet been fully elucidated, several investigators have demonstrated through human and animal studies, the association of androgens, especially testosterone with hypertension.The purpose of the study was to determine maternal serum levels of androgens, especially testosterone, in patients with preeclampsia and its comparison with normotensive control subjects.Serum testosterone, dehydroepiandrosterone sulfate levels were measured in 30 subjects in the third trimester of pregnancy with documented preeclampsia and 30 healthy, normotensive women with similar maternal and gestational ages.All subjects were primigravid women with singleton pregnancies who referred to Asali Hospital.Total testosterone and free testosterone levels were significantly higher in patients with preeclampsia (206.2 ng/dl and 0.5 ng/dl) than in the control group (158.8 ng/dl and 0.2 ng/dl). There were no significant differences in dehydroepiandrosterone sulfate and maternal age, gestational age, body mass index and neonatal sex.Levels of the potent andreogen testosterone were significantly higher in primigravid women with preeclampsia than in normotensive women with similar gestational and maternal ages.This difference may indicate a role for testosteron in the pathogenesis of preeclampsia.