مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Effects of Sodium Selenite and Vitamin E on the Development of Morphine Dependency in Mice

Pages

  339-344

Abstract

 Background: Antioxidant drugs may be useful in preventing morphine-induced dependency by suppressing oxidative stress. Vitamin E which has many essential roles in the body is a powerful antioxidant. On the other hand, selenium is an essential trace element that plays a strong role in various biochemical pathways. The aim of this study was to investigate the effects of sodium selenite and vitamin E on morphine-induced dependency in mice. Methods: Ninety male mice, weighing 20 to 30 g, were randomly divided into 10 groups and were treated as follows: a) saline and b) morphine groups were pretreated (for 2 days) with normal saline (10 ml. kg-1. day-1, ip) then daily doses of normal saline (10 ml. kg-1. day-1, ip) and morphine (50 mg. kg-1. day-1) were added to the injections for the following 4 days, respectively. c, d, e) sodium selenite, f, g, h) vitamin E, i) vitamin E solvent (almond oil) and j) co-administration groups were pretreated (for 2 days) with sodium selenite (0. 25, 0. 5, 1 mg. kg-1. day-1, ip), vitamin E (20, 40, 60 IU. kg-1. day-1, ip), vitamin E solvent (10 ml. kg-1. day-1, ip) and combination of the drugs respectively, then morphine doses (50 mg. kg-1. day-1, ip) were added to the injections for the following 4 days. Withdrawal symptoms were evaluated after injecting naloxone (4 mg/kg/ day). Biochemical evaluations were also performed. Results: The results showed that co-administration of sodium selenite and vitamin E (at low doses) significantly reduced morphine dependency (p < 0. 05). Conclusion: The synergistic effect of sodium selenite and vitamin E can be a suitable and efficient approach to reduce dependency.

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    APA: Copy

    HABIBI ASL, BOHLOUL, Parvizpur, Alireza, Fekri, Kiarash, Jahanpanah, Hadis, Rezaei, Hadis, & CHARKHPOUR, MOHAMMAD. (2021). Effects of Sodium Selenite and Vitamin E on the Development of Morphine Dependency in Mice. PHARMACEUTICAL SCIENCES, 27(3), 339-344. SID. https://sid.ir/paper/979729/en

    Vancouver: Copy

    HABIBI ASL BOHLOUL, Parvizpur Alireza, Fekri Kiarash, Jahanpanah Hadis, Rezaei Hadis, CHARKHPOUR MOHAMMAD. Effects of Sodium Selenite and Vitamin E on the Development of Morphine Dependency in Mice. PHARMACEUTICAL SCIENCES[Internet]. 2021;27(3):339-344. Available from: https://sid.ir/paper/979729/en

    IEEE: Copy

    BOHLOUL HABIBI ASL, Alireza Parvizpur, Kiarash Fekri, Hadis Jahanpanah, Hadis Rezaei, and MOHAMMAD CHARKHPOUR, “Effects of Sodium Selenite and Vitamin E on the Development of Morphine Dependency in Mice,” PHARMACEUTICAL SCIENCES, vol. 27, no. 3, pp. 339–344, 2021, [Online]. Available: https://sid.ir/paper/979729/en

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