مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Seminar Paper

Title

ANGIOTENSIN CONVERTING ENZYME INHIBITION AMELIORATES HYPERLIPIDEMIA, INFLAMMATORY AND ANGIOGENIC FACTORS IN HYPERCHOLESTEROLEMIC RATS

Pages

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Abstract

 INTRODUCTION: RENIN – ANGIOTENSIN SYSTEM (RAS) CAN BE ACTIVATED DURING HYPERLIPIDEMIA. ANGIOTENSIN II INCREASES THE MIGRATION OF MONOCYTES, CYTOKINE LEVEL AND GENE EXPRESSIONS OF VEGF AND VCAM-1. WE AIMED TO INVESTIGATE THE EFFECT OF ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITION ON VEGF, VCAM-1 AND NITRIC OXIDE (NO) LEVELS IN HYPERCHOLESTEROLEMIC RATS.METHODS: FORTY MALE WISTAR RATS WERE DIVIDED INTO 4 GROUPS INCLUDING; NORMAL DIET + SALINE (CONTROL); HYPER CHOLESTEROL DIET + SALINE INJECTION; NORMAL DIET + CAPTOPRIL INJECTION AND HYPER CHOLESTEROL DIET + CAPTOPRIL INJECTION. BEFORE AND AFTER THE DIET AND AFTER THE TREATMENT, SERUM LEVELS OF CHOLESTEROL, TRIGLYCERIDES, LDL, HDL, AND NO WERE MEASURED FINALLY GENE EXPRESSIONS OF VCAM-1 AND VEGF WERE DETERMINED.RESULTS: HYPERCHOLESTEROLEMIC DIET INCREASED THE SERUM LEVELS OF CHOLESTEROL, LDL (P<0.001) AND TRIGLYCERIDES (P < 0.01); AND DECREASED HDL (P < 0.001). CAPTOPRIL REDUCED THE SERUM LEVELS OF CHOLESTEROL, LDL (P < 0.001) AND TRIGLYCERIDES (P < 0.05) AS WELL AS WELL AS INCREASED HDL LEVEL (P < 0.01). HOWEVER THE SERUM LEVEL OF NO WAS DECREASED AFTER HYPERCHOLESTEROLEMIC DIET (P < 0.001) BUT NO SIGNIFICANT CHANGE WAS OBSERVED AFTER TREATMENT. INCREASED GENE EXPRESSIONS OF VEGF (P < 0.05) AND VCAM-1 (P < 0.01) IN HYPERCHOLESTEROLEMIA WERE REGRESSED IN CAPTOPRIL TREATED RATS, P < 0.01 AND P < 0.05, RESPECTIVELY.CONCLUSION: ACE INHIBITORS LIKE CAPTOPRIL IMPROVE HYPERLIPIDEMIA, PREVENT OVER-EXPRESSION OF SOME GENES (E.G. VEGF AND VCAM-1) THAT COULD BE IMPLICATED IN THE INFLAMMATION AND ANGIOGENESIS.

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    APA: Copy

    MAHMOUDABADY, MARYAM, Kazemi, Narges, NIAZMAND, SAEED, REZAEE, SEYYED ABDOLRAHIM, & SOUKHTANLOO, MOHAMMAD. (2015). ANGIOTENSIN CONVERTING ENZYME INHIBITION AMELIORATES HYPERLIPIDEMIA, INFLAMMATORY AND ANGIOGENIC FACTORS IN HYPERCHOLESTEROLEMIC RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/921601/en

    Vancouver: Copy

    MAHMOUDABADY MARYAM, Kazemi Narges, NIAZMAND SAEED, REZAEE SEYYED ABDOLRAHIM, SOUKHTANLOO MOHAMMAD. ANGIOTENSIN CONVERTING ENZYME INHIBITION AMELIORATES HYPERLIPIDEMIA, INFLAMMATORY AND ANGIOGENIC FACTORS IN HYPERCHOLESTEROLEMIC RATS. 2015. Available from: https://sid.ir/paper/921601/en

    IEEE: Copy

    MARYAM MAHMOUDABADY, Narges Kazemi, SAEED NIAZMAND, SEYYED ABDOLRAHIM REZAEE, and MOHAMMAD SOUKHTANLOO, “ANGIOTENSIN CONVERTING ENZYME INHIBITION AMELIORATES HYPERLIPIDEMIA, INFLAMMATORY AND ANGIOGENIC FACTORS IN HYPERCHOLESTEROLEMIC RATS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2015, [Online]. Available: https://sid.ir/paper/921601/en

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