THE ROLE OF CA1 GLIAL CELLS ON AUGMENTED LTP IN MORPHINE-DEPENDENT RATS

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Elahi Mahani Azadeh; HOSSEINMARDI NARGES; JANAHMADI MAHYAR; Seyedaghamiri Fatemehsadat; Hooshmandi Mehdi

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Seminar Paper

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2015 | Issue:22

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Title

THE ROLE OF CA1 GLIAL CELLS ON AUGMENTED LTP IN MORPHINE-DEPENDENT RATS

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Keywords

MORPHINE DEPENDENCE

SYNAPTIC PLASTICITY

GLIA

CA1 AREA OF THE HIPPOCAMPUS

FIELD POTENTIAL RECORDING

Abstract

INTRODUCTION: MORPHINE DEPENDENCE MODIFIES HIPPOCAMPAL SYNAPTIC PLASTICITY. CONSIDERING THE INCREASED ACTIVITY OF HIPPOCAMPAL MICRGLIA AND ASTROCYTES DUE TO MORPHINE ADMINISTRATION, IT IS PROBABLE THAT MORPHINE EFFECTS ON CA1 NEURONAL FUNCTION AND THEREFORE ON BEHAVIORAL CHANGES SUCH AS DEPENDENCE IS MEDIATED BY GLIAL CELLS.METHODS: AFTER MAKING RATS DEPENDENT TO MORPHINE BY SUBCUTANEOUS INJECTION OF MORPHINE SULFATE (10 MG/KG) AT AN INTERVAL OF 12 H FOR 9 DAYS, LONG TERM POTENTIATION (LTP) WERE ASSESSED BY IN VIVO FIELD POTENTIAL RECORDING, IN MORPHINE DEPENDENT RATS, IN DEPENDENT RATS RECEIVED FLUOROCITRATE, GLIAL CELLS INHIBITORS, (1NMOL/1 ML) BILATERALLY INTO THE HIPPOCAMPUS 120 MIN BEFORE MORPHINE INJECTION. FIELD EXCITATORY POST SYNAPTIC POTENTIALS (FEPSP) WERE RECORDED FROM STRATUM RADIATUM OF AREA CA1 FOLLOWING SCHAFFER COLLATERAL STIMULATION. TO INDUCE LONG TERM POTENTIATION (LTP), A 200 HZ TETANIC STIMULATION WAS USED.RESULTS: MORPHINE DEPENDENCE CAUSED AUGMENTED LTP IN CA1 AREA. FEPSP SLOPE POTENTIATION IN THIS GROUP (51.23±17.07%) WAS STATISTICALLY (UNPAIRED T-TEST, P<0.01) MORE THAN CONTROL ANIMALS (17.49±4.14%). ANIMALS RECEIVING INTRAHIPPOCAMPAL MICROINJECTION OF FLUOROCITRATE BEFORE MORPHINE, DEMONSTRATED A SIGNIFICANT REDUCTION (UNPAIRED T-TEST, P<0.001) IN POTENTIATION (12.44±10.34%) COMPARED TO THOSE WHICH RECEIVED VEHICLE (72.80±12.16%).CONCLUSION: THESES DATA SUGGEST THAT HIPPOCAMPAL GLIAL CELLS MEDIATE SOME EFFECTS OF MORPHINE ON CA1 SYNAPTIC PLASTICITY.

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APA: Copy

Elahi Mahani, Azadeh, HOSSEINMARDI, NARGES, JANAHMADI, MAHYAR, Seyedaghamiri, Fatemehsadat, & Hooshmandi, Mehdi. (2015). THE ROLE OF CA1 GLIAL CELLS ON AUGMENTED LTP IN MORPHINE-DEPENDENT RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/920880/en

Vancouver: Copy

Elahi Mahani Azadeh, HOSSEINMARDI NARGES, JANAHMADI MAHYAR, Seyedaghamiri Fatemehsadat, Hooshmandi Mehdi. THE ROLE OF CA1 GLIAL CELLS ON AUGMENTED LTP IN MORPHINE-DEPENDENT RATS. 2015. Available from: https://sid.ir/paper/920880/en

IEEE: Copy

Azadeh Elahi Mahani, NARGES HOSSEINMARDI, MAHYAR JANAHMADI, Fatemehsadat Seyedaghamiri, and Mehdi Hooshmandi, “THE ROLE OF CA1 GLIAL CELLS ON AUGMENTED LTP IN MORPHINE-DEPENDENT RATS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2015, [Online]. Available: https://sid.ir/paper/920880/en

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