EFFECT OF CURCUMIN ON THE GLIAL SCAR FORMATION FOLLOWING ACUTE SPINAL CORD INJURY

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BARATI PARASTOO; Roshanaii Kambiz; DARVISHI MARZIEH

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2015 | Issue:22

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Title

EFFECT OF CURCUMIN ON THE GLIAL SCAR FORMATION FOLLOWING ACUTE SPINAL CORD INJURY

Author(s)

BARATI PARASTOO | Roshanaii Kambiz | DARVISHI MARZIEH | Issue Writer Certificate

Keywords

ASTROCYTES

GLIAL SCAR

SPINAL INJURY

REGENERATION

INFLAMMATION

CURCUMIN

Abstract

INTRODUCTION: MANY STUDIES HAVE ILLUSTRATED THAT MUCH OF THE POST-TRAUMATIC DEGENERATION OF THE SPINAL CORD FOLLOWING INJURY IS CAUSED BY A SECONDARY INJURY PROCESS THAT OCCURS AFTER SPINAL CORD INJURY (SCI). A BIOCHEMICAL EVENT IN THAT PROCESS IS INFLAMMATION AND GLIOSIS. CURCUMIN (DIFERULOYLMETHANE) IS A HIGHLY PLEIOTROPIC MOLECULE WITH POTENT ANTI-INFLAMMATORY PROPERTIES WHICH POTENTLY INHIBITS NF-ΚB. THE AIM IN THE PRESENT STUDY WAS TO EXAMINE EFFECT OF CURCUMIN ON GLIOSIS AND AXONAL REGENERATION SOUGHT TO FUNCTIONAL RECOVERY AFTER ACUTE SPINAL CORD INJURY IN CONTUSION MODEL OF RATS.METHODS: RAT MODELS RECEIVING DAILY INTRAPERITONEAL INJECTIONS OF 5 DIFFERENT DOSES (150, 200, 300, 400 AND 500 MG/KG), AFTER SCI OR SHAM SURGERY. THREE MONTH AFTER SURGERY SPINAL CORD WAS EXAMINED HISTOLOGICALLY, EXPRESSION OF GLIAL FIBRILLARY ACID PROTEIN (GFAP).RESULTS: THE IMMUNOHISTOCHEMICAL STUDIES WERE DONE WITH IMMUNOFLUORESCENT AND IMMUNE PEROXIDASE TECHNIQUES 12 WEEKS POST-SURGERY. THE EXPRESSION OF GFAP IN THE UNTREATED CONTROLS HAD THE HIGHEST IMMUNOFLUORESENCE WHILE IT WAS SIGNIFICANTLY DECREASED IN THE ALL OF CURCUMIN GROUP (P<0.05).CONCLUSION: QUANTITATIVE ANALYSIS SHOWED THAT THERE IS A DOSE DEPENDENT DECREASE IN THE RELATIVE INTENSITY OF THE GFAP FLUORESCENT AT ALL OF CURCUMIN GROUP AND INDICATE THAT THE EFFECT OF CURCUMIN EXTENDS BEYOND ITS KNOWN ANTI-INFLAMMATORY PROPERTIES TO THE REGULATION OF STEM CELL PROLIFERATION.

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APA: Copy

BARATI, PARASTOO, Roshanaii, Kambiz, & DARVISHI, MARZIEH. (2015). EFFECT OF CURCUMIN ON THE GLIAL SCAR FORMATION FOLLOWING ACUTE SPINAL CORD INJURY. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/920674/en

Vancouver: Copy

BARATI PARASTOO, Roshanaii Kambiz, DARVISHI MARZIEH. EFFECT OF CURCUMIN ON THE GLIAL SCAR FORMATION FOLLOWING ACUTE SPINAL CORD INJURY. 2015. Available from: https://sid.ir/paper/920674/en

IEEE: Copy

PARASTOO BARATI, Kambiz Roshanaii, and MARZIEH DARVISHI, “EFFECT OF CURCUMIN ON THE GLIAL SCAR FORMATION FOLLOWING ACUTE SPINAL CORD INJURY,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2015, [Online]. Available: https://sid.ir/paper/920674/en

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