SOLUBILITY ENHANCEMENT OF VALSARTAN DRUG BY USING O/W MICRO EMULSION SYSTEM

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Najafabadi farahani S.; SALABAT A.

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Seminar Paper

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Seminar: IRANIAN CHEMISTRY CONGRESS
Year:2013 | Issue:16

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Title

SOLUBILITY ENHANCEMENT OF VALSARTAN DRUG BY USING O/W MICRO EMULSION SYSTEM

Author(s)

Najafabadi farahani S. | SALABAT A. | Issue Writer Certificate

Keywords

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Abstract

VALSARTAN IS USED TO TREAT HIGH BLOOD PRESSURE (HYPERTENSION) AND HEART FAILURE. IT IS ALSO USED TO IMPROVE THE CHANCE OF LIVING LONGER AFTER A HEART ATTACK. VALSARTAN IS POORLY SOLUBLE AND CAN BE CONSIDERED A CLASS II COMPOUND THAT WATER-INSOLUBLE, LIPOPHILIC AND HIGHLY PERMEABLE COMPOUND AND THE DRUG IS RAPIDLY ABSORBED FOLLOWING ORAL ADMINISTRATION, WITH A BIOAVAILABILITY OF ABOUT 25% [1]. IT IS POSSIBLE TO IMPROVE THE DRUGS BIOAVAILABILITY BY INCREASING ITS APPARENT SOLUBILITY IN WATER THROUGH MICROEMULSION [2, 3].THE AIM OF THIS STUDY IS TO DESIGN AND DEVELOP MICRO EMULSION OF VALSARTAN FOR ENHANCING ITS SOLUBILITY, HENCE THE ORAL BIOAVAILABILITY.FIRST OF ALL, IN ORDER TO FORMULATION OF O/W MICRO EMULSION SYSTEM, THE OLEIC ACID AS OIL PHASE, TWEEN 80 AS SURFACTANT, AND ISOBUTANOL AS CO-SURFACTANT WERE SELECTED. FOR THIS SYSTEM PSEUDO-TERNARY PHASE DIAGRAM OF THE SYSTEM WAS CONSTRUCTED TO IDENTIFY THE MICRO EMULSION EXISTING ZONE (FIG1). FOR CONSTRUCTING OF PHASE DIAGRAM, DIFFERENT OIL TO WATER RATIO WAS TITRATED WITH SURFACTANT AND CO-SURFACTANT MIX WITH MAGNETIC STIRRING AT ROOM TEMPERATURE UNTIL THE SYSTEM WAS TRANSPARENT. IN ALL EXPERIMENTS SURFACTANT TO COSURFACTANT VOLUME RATIO WAS 2.4: 1.THE OBTAINED MICROEMULSION SYSTEM WAS MIXED WITH VALSARTAN. CONCENTRATION OF VALSARTAN IN THE SAMPLES WAS QUANTIFIED SPECTROPHOTOMETRIC ALLY IN A UV-VISIBLE SPECTROPHOTOMETER.THE OBTAINED RESULTS SHOW THAT THE SOLUBILITY OF VALSARTAN INCREASED CONSIDERABLY IN THE FORMULATED MICRO EMULSION.

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APA: Copy

Najafabadi farahani, S., & SALABAT, A.. (2013). SOLUBILITY ENHANCEMENT OF VALSARTAN DRUG BY USING O/W MICRO EMULSION SYSTEM. IRANIAN CHEMISTRY CONGRESS. SID. https://sid.ir/paper/915817/en

Vancouver: Copy

Najafabadi farahani S., SALABAT A.. SOLUBILITY ENHANCEMENT OF VALSARTAN DRUG BY USING O/W MICRO EMULSION SYSTEM. 2013. Available from: https://sid.ir/paper/915817/en

IEEE: Copy

S. Najafabadi farahani, and A. SALABAT, “SOLUBILITY ENHANCEMENT OF VALSARTAN DRUG BY USING O/W MICRO EMULSION SYSTEM,” presented at the IRANIAN CHEMISTRY CONGRESS. 2013, [Online]. Available: https://sid.ir/paper/915817/en

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