EFFECTS OF ETHOSUXIMIDE ON MORPHINE TOLERANCE AND DEPENDENCE IN MICE

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IMEN SHAHIDI M.; HOSSEINZADEH H.; ESHAGHIAN A.

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

EFFECTS OF ETHOSUXIMIDE ON MORPHINE TOLERANCE AND DEPENDENCE IN MICE

Author(s)

IMEN SHAHIDI M. | HOSSEINZADEH H. | ESHAGHIAN A.

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Abstract

Introduction: In this study, the effects of ethosuximide (an anticonvulsant with T-type calcium channel blocking activity) on the expression and development of morphine antinociceptive tolerance, and naloxone-precipitated abstinence syndrome in morphine dependent mice were investigated.Methods: Mice were rendered tolerant and dependent on morphine by repeated administration of morphine. The tail-flick test was used to assess the nociceptive threshold, naloxone-induced jumping to assess the morphine dependence and open field to evaluate the locomotion.Results: Repeated administration of ethosuximide (100, 200 and 400 mg/kg, 2time/day for 4 day) and also single administration of ethosuximide (100 mg/kg, simultaneously with last dose of morphine) reduced the development and expression of tolerance to the antinociceptive effect of morphine. Repeated administration of ethosuximide (100, 200 and 400 mg/kg, 3 time /day for 3 day) and also single administration of ethosuximide (100, 200 and 400 mg/kg, 30 min before the last dose of morphine) reduced the development and expression of naloxone-induced jumping in dependent mice that was comparable with clonidine (0.1 mg/kg) as positive control. Single (200 and 400 mg/kg) and repeated (only in 400 mg/ kg) administration of ethosuximide reduced the activity of animals in open field test. Ethosuximide in 200 and 400 mg/kg had direct antinociceptive effect that wasn't blocked by naloxone.Conclusion: These results showed that ethosuximide, a relatively selective T-type calcium channel blocker has direct antinociceptive effect, prevents the development and expression of antinociceptive tolerance to morphine and suppress morphine withdrawal syndrome.

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APA: Copy

IMEN SHAHIDI, M., HOSSEINZADEH, H., & ESHAGHIAN, A.. (2007). EFFECTS OF ETHOSUXIMIDE ON MORPHINE TOLERANCE AND DEPENDENCE IN MICE. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904544/en

Vancouver: Copy

IMEN SHAHIDI M., HOSSEINZADEH H., ESHAGHIAN A.. EFFECTS OF ETHOSUXIMIDE ON MORPHINE TOLERANCE AND DEPENDENCE IN MICE. 2007. Available from: https://sid.ir/paper/904544/en

IEEE: Copy

M. IMEN SHAHIDI, H. HOSSEINZADEH, and A. ESHAGHIAN, “EFFECTS OF ETHOSUXIMIDE ON MORPHINE TOLERANCE AND DEPENDENCE IN MICE,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904544/en

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