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Title

COMPARISON OF THE EFFECT PROPRANOLOL, CAFFEINE AND DIAZEPAM ON LIDOCACAINE INDUCED CONVULSION IN MICE

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Abstract

 Propranolol has cardiovascular and also central effects. At this study, the effect of propanolol was compared with caffeine and diazpam on convulsion induced by lidocaine in mice. The study was done on 4 groups of mice. Lidocaine was administted at dose 30mg/kg – ip in group 1. Diazpam was injected at dose 2mg/kg-ip 15 min before lidocaine in group 2. Proranolol was injected at dose 5mg/kg-ip 15 min before lidocaine in group 3. Caffeine was injected at dose 10mg/kg+ip15 min before lidocaine in group 4. The initiation, number and duration of convulsion were counted in mice and the mean of these factors was evaluated. In group 1, the convulsion initiated 5 min after lidocaine injection and the mean and the number of convulsions was 3.5 min and 22, respectively. No convulsion was seen with diazpam. The convulsion was seen at two mice of group 3 and 4. Thus, the results of this study show that propranolol and caffeine can reduce lidocaineinduced convulsion.

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    APA: Copy

    BAKHTIARI, ELHAM, MEHRZADI, SAEID, & NAJAFZADEH VARZI, H.. (2009). COMPARISON OF THE EFFECT PROPRANOLOL, CAFFEINE AND DIAZEPAM ON LIDOCACAINE INDUCED CONVULSION IN MICE. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903744/en

    Vancouver: Copy

    BAKHTIARI ELHAM, MEHRZADI SAEID, NAJAFZADEH VARZI H.. COMPARISON OF THE EFFECT PROPRANOLOL, CAFFEINE AND DIAZEPAM ON LIDOCACAINE INDUCED CONVULSION IN MICE. 2009. Available from: https://sid.ir/paper/903744/en

    IEEE: Copy

    ELHAM BAKHTIARI, SAEID MEHRZADI, and H. NAJAFZADEH VARZI, “COMPARISON OF THE EFFECT PROPRANOLOL, CAFFEINE AND DIAZEPAM ON LIDOCACAINE INDUCED CONVULSION IN MICE,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903744/en

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    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
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