DISCRIMINATION OF IRON DEFICIENCY ANEMIA AND BETA THALASSEMIA MINOR BASED ON A NEW INDEX

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EHSANI M.A.; SOTOUDEH K.; SHAHGHOLI E.; RAHIMINEZHAD M.S.; SEYGHALI F.; ASLANI AFSHIN

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Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION Year:2007 | Volume:4 | Issue:3 (15) Page(s): 215-221

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Title

DISCRIMINATION OF IRON DEFICIENCY ANEMIA AND BETA THALASSEMIA MINOR BASED ON A NEW INDEX

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Keywords

IRON DEFICIENCY ANEMIAQ3

BETA THALASSEMIAQ4

ERYTHROCYTE INDICESQ4

Abstract

Background and Objectives: Iron deficiency anemia (IDA) and beta thalassemia minor (BTM) are the most common causes of hypochromic microcytic anemia. Many indices have been defined for rapid differentiation of these diseases via red blood cell indices. The objectives of this study were to introduce a new index, evaluate its validity, and compare it with other indices.Materials and Methods: In this descriptive observational study, new patients with hypochromic microcytic anemia referred to hematology clinic were studied. 130 patients with IDA and 154 with BTM with the mean age of 24.2 years were assessed. Inclusion criteria were anemia [Hemoglobin (Hb) <mean ± 2 SD for age and sex] and Mean corpuscular volume (MCV) < 80 fl in patients over 6 years and MCV < [70 + Age (year)] fl for patients under 6 years of age. Exclusion criteria were pregnancy, anemia due to multifactorial causes, other hemoglobinopathies and chronic diseases. For all patients, serum iron, serum iron binding capacity, serum ferritin, and HbA2 were measured. BTM and IDA diagnoses were confirmed with HbA2>3.5% and ferritin<12 ng/ml or anemia responding to iron respectively. All patients were assessed according to red blood cell (RBC), Mentzer index, England index, Srivastava index and red cell distribution width, and our new index: [MCV-(10.RBC)]. Sensitivity, specificity, as well as Youden's index have been calculated for all indices.Results: Only Mentzer index and the newly introduced index had the sensitivity and specificity of over 90%. Mentzer Index and the newly introduced index had the highest Youden's index.Conclusions: Compared to other well-known indices, the newly introduced index is straightforward and has a good sensitivity and specificity to discriminate IDA and BTM. Its calculation is easy and does not need calculator.

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APA: Copy

EHSANI, M.A., SOTOUDEH, K., SHAHGHOLI, E., RAHIMINEZHAD, M.S., SEYGHALI, F., & ASLANI, AFSHIN. (2007). DISCRIMINATION OF IRON DEFICIENCY ANEMIA AND BETA THALASSEMIA MINOR BASED ON A NEW INDEX. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 4(3 (15)), 215-221. SID. https://sid.ir/paper/78490/en

Vancouver: Copy

EHSANI M.A., SOTOUDEH K., SHAHGHOLI E., RAHIMINEZHAD M.S., SEYGHALI F., ASLANI AFSHIN. DISCRIMINATION OF IRON DEFICIENCY ANEMIA AND BETA THALASSEMIA MINOR BASED ON A NEW INDEX. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2007;4(3 (15)):215-221. Available from: https://sid.ir/paper/78490/en

IEEE: Copy

M.A. EHSANI, K. SOTOUDEH, E. SHAHGHOLI, M.S. RAHIMINEZHAD, F. SEYGHALI, and AFSHIN ASLANI, “DISCRIMINATION OF IRON DEFICIENCY ANEMIA AND BETA THALASSEMIA MINOR BASED ON A NEW INDEX,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 4, no. 3 (15), pp. 215–221, 2007, [Online]. Available: https://sid.ir/paper/78490/en

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