ANTI-INFLAMMATION EFFECT OF ALCOHOLIC EXTRACT OF LINUM USITATISSIMUM L. IN MALE RATS

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EBRAHIMI VOSTA KALAEE S.; TALEBI MAZRAEH SHAHI A.; NASERI M.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES Year:2014 | Volume:16 | Issue:4 Page(s): 50-56

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Title

ANTI-INFLAMMATION EFFECT OF ALCOHOLIC EXTRACT OF LINUM USITATISSIMUM L. IN MALE RATS

Author(s)

EBRAHIMI VOSTA KALAEE S. | TALEBI MAZRAEH SHAHI A. | NASERI M. | Issue Writer Certificate

Keywords

FLAXSEEDQ2

CARRAGEENANQ2

XYLENEQ2

OVALBUMINQ3

RATQ2

Abstract

BACKGROUND AND OBJECTIVE: The anti-inflammatory drugs are associated with the wide side effect. The herbal medicine has fewer side effects. Numerous references to anti-inflammatory effects of Linum usitatissimum L. have been noted in our traditional medicine. In the present study, anti-inflammatory effects of flaxseed extract has been studied and with anti-inflammatory effects of sodium salicylate was compared.METHODS: In this experimental study 90 male albino rats (weighing 200-300 gr) were used. Animals were randomly divided into 15 groups (n=6): positive control (sodium salicylate 200 mg/kg i.p.), negative control (DMSO 10%, 10 ml/kg i.p.) and treatment groups received extract (100, 200, 400 mg/kg i.p.) in a similar volume. Flaxseed hydroalcholic extract was prepared by maceration. Half an hour after, inflammation was induced by injection (s.c.) 0.1 ml Carrageenan (1% w/v in saline solution) into the hind paw or 0.03 ml xylene behind the ear and or 1 ml_ovalbumin (2%) into the hind paw. The paw volume was measured with plethysmometer in 1, 2, and 3 h after the carrageenan (or ovalbumin) injection. In xylene test, 0.03 ml of xylene was injected to the posterior surfaces of the right ear and the weight of two ears after 2 h was also compared.FINDINGS: The results showed that all doses of Flaxseed hydroalcoholic extract in dose-dependent manner significantly reduced inflammation in both acute and chronic phases in compared with the negative control group (p<0.05, p<0.01). The extract (400 mg/kg) reduced inflammation in Carrageenan test 56%, the albumin 69%, and xylene 60% when compared with anti-inflammatory effects of sodium Salyslat (50%).CONCLUSION: The results of this study showed that flaxseed extract has significant anti-inflammatory effects but to understand the possible mechanism of this effect, additional research is needed.

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APA: Copy

EBRAHIMI VOSTA KALAEE, S., TALEBI MAZRAEH SHAHI, A., & NASERI, M.. (2014). ANTI-INFLAMMATION EFFECT OF ALCOHOLIC EXTRACT OF LINUM USITATISSIMUM L. IN MALE RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 16(4), 50-56. SID. https://sid.ir/paper/73708/en

Vancouver: Copy

EBRAHIMI VOSTA KALAEE S., TALEBI MAZRAEH SHAHI A., NASERI M.. ANTI-INFLAMMATION EFFECT OF ALCOHOLIC EXTRACT OF LINUM USITATISSIMUM L. IN MALE RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2014;16(4):50-56. Available from: https://sid.ir/paper/73708/en

IEEE: Copy

S. EBRAHIMI VOSTA KALAEE, A. TALEBI MAZRAEH SHAHI, and M. NASERI, “ANTI-INFLAMMATION EFFECT OF ALCOHOLIC EXTRACT OF LINUM USITATISSIMUM L. IN MALE RATS,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 16, no. 4, pp. 50–56, 2014, [Online]. Available: https://sid.ir/paper/73708/en

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