EFFECTS OF VITAMIN D TREATMENT ON THYROID AUTOIMMUNITY

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SIMSEK YASIN; CAKIR ILKAY; YETMIS MIKAIL; SITKI DIZDAR OGUZHAN; BASPINAR OSMAN; GOKAY FERHAT

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2016 | Volume:21 | Issue:6 Page(s): 0-0

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Title

EFFECTS OF VITAMIN D TREATMENT ON THYROID AUTOIMMUNITY

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Keywords

AUTOIMMUNE THYROID DISEASES

THYROID ANTIBODIES

VITAMIN D

Abstract

Background: Vitamin D was shown to be related to autoimmune thyroid diseases (AITDs) in the previous studies. We aimed to investigate the relationship between Vitamin D and thyroid autoimmunity. Materials and Methods: Eighty‑two patients, diagnosed with AITD by the endocrinology outpatient clinic, were included in this prospective study. All of the patients had both AITD and Vitamin D deficiency, defined as serum values <20 ng/mL. They were randomly assigned into two groups. The first group included 46 patients and the second one included 36 patients. The first group was treated with Vitamin D for 1 month at 1000 IU/day. The second group served as the control group and was not treated with Vitamin D replacement. Serum thyroid‑stimulating hormone, free T4 (fT4), thyroid peroxidase antibody (TPO‑Ab), thyroglobulin antibody (TgAb), and Vitamin D levels were measured at the initiation of the study and again at 1 month in all patients. Results: Two groups were similar with regard to age, sex, and type of thyroid disease. Whereas TPO‑Ab (before; 278.3 ± 218.4 IU/ml and after; 267.9 ± 200.7 IU/ml) and TgAb (before; 331.9 ± 268.1 IU/ml and after; 275.4 ± 187.3 IU/ml) levels were significantly decreased by the Vitamin D replacement therapy in group 1 (P = 0.02, P = 0.03, respectively), the evaluated parameters in the control group did not significantly change (P = 0.869, P = 0.530, respectively). In addition, thyroid function tests did not significantly change with Vitamin D replacement in two groups. Conclusion: Vitamin D deficiency may contribute to the pathogenesis of AITDs. Since supplementation of the Vitamin D decreased thyroid antibody titers in this study in Vitamin D deficient subjects, in the future Vitamin D may become a part of AITDs’ treatment, especially in those with Vitamin D insufficiency. Further clinical and experimental studies are required to understand the effect of Vitamin D on AITD.

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APA: Copy

SIMSEK, YASIN, CAKIR, ILKAY, YETMIS, MIKAIL, SITKI DIZDAR, OGUZHAN, BASPINAR, OSMAN, & GOKAY, FERHAT. (2016). EFFECTS OF VITAMIN D TREATMENT ON THYROID AUTOIMMUNITY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(6), 0-0. SID. https://sid.ir/paper/688512/en

Vancouver: Copy

SIMSEK YASIN, CAKIR ILKAY, YETMIS MIKAIL, SITKI DIZDAR OGUZHAN, BASPINAR OSMAN, GOKAY FERHAT. EFFECTS OF VITAMIN D TREATMENT ON THYROID AUTOIMMUNITY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(6):0-0. Available from: https://sid.ir/paper/688512/en

IEEE: Copy

YASIN SIMSEK, ILKAY CAKIR, MIKAIL YETMIS, OGUZHAN SITKI DIZDAR, OSMAN BASPINAR, and FERHAT GOKAY, “EFFECTS OF VITAMIN D TREATMENT ON THYROID AUTOIMMUNITY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 6, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/688512/en

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