مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

Tumor Microenvironment: Involved Factors and Signaling Pathways in Epithelial-Mesenchymal Transition

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Abstract

 Context: Metastasis is a main cause of death in patients with Cancer, whereby tumor cells withdraw from the primary site of the tumor mass and produce secondary tumor mass in new sites. Primary tumor cells depart collectively and individually to invade closed and distant sites. Evidence Acquisition: This review considers TME-derived factors that actuate signaling Pathways to induce epithelialmesenchymal transition (EMT). National Center for Biotechnology Information (NCBI) was the main resource. Google Scholar and Scopus were other databases for finding articles. Keywords that were inserted into the search box of databases to identify related articles were ‘ Metastasis’ , ‘ invasion’ , ‘ epithelial-mesenchymal transition’ , ‘ EMT’ , ‘ tumor microenvironment’ , ‘ TME’ , ‘ TME cells’ , and ‘ signaling pathway in EMT’ . Titles and abstracts of the articles were studied to choose the right articles. Finally, 107 articles were selected to study in detail and use as references. Results: EMT is a type of Metastasis that deprives epithelial single-cells of their characteristic features and acquires mesenchymal features facilitating the departure from the primary tumor mass. During EMT, cell-adhesion and apical-basal polarity rapture and cells obtainmovementcapability. The tumor microenvironment (TME) leadsEMTthrough secretion factors and signaling Pathways. As a result of activating these Pathways, Transcription Factors that abolish epithelial gene expressions and augment mesenchymal gene expression are induced. Conclusions: In this review, recent research published in TME and EMT fields were highlighted and critically appraised. Effect of factors-derivedTMEcells onEMTwere manifested that propose favorite targets for a therapeutic goal to inhibit Metastasis. However, data about the effect of the combination of TME cells on Metastasis have a small part in the literature.

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    APA: Copy

    Ghaderi, Madeh, & Niknejad, Azadeh. (2021). Tumor Microenvironment: Involved Factors and Signaling Pathways in Epithelial-Mesenchymal Transition. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 14(7), 0-0. SID. https://sid.ir/paper/683847/en

    Vancouver: Copy

    Ghaderi Madeh, Niknejad Azadeh. Tumor Microenvironment: Involved Factors and Signaling Pathways in Epithelial-Mesenchymal Transition. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2021;14(7):0-0. Available from: https://sid.ir/paper/683847/en

    IEEE: Copy

    Madeh Ghaderi, and Azadeh Niknejad, “Tumor Microenvironment: Involved Factors and Signaling Pathways in Epithelial-Mesenchymal Transition,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 14, no. 7, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/683847/en

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