Investigating the CYP2B6 rs3745274 and rs3211371 Polymorphisms in Methadone-Responder and Non-Responder Addicts in Iran

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Aghabozorg Afjeh Sara Sadat; BOSHEHRI BEHZAD; HAMEDNIA SAFAR; Amini Asmaolhosna; MASHAYEKHI PARISA; OMRANI MIR DAVOOD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Biomedical Journal Year:2021 | Volume:25 | Issue:3 Page(s): 220-225

Download Full-Text

View:

116

Download:

105

Cites:

Information Journal Paper

Title

Investigating the CYP2B6 rs3745274 and rs3211371 Polymorphisms in Methadone-Responder and Non-Responder Addicts in Iran

Author(s)

Keywords

Addiction

Biomarker

Methadone

Single-nucleotide polymorphism

Abstract

Background: Methadone therapy is a major protocol in opioid Addiction cases in many health care systems. Population-based studies have shown that in addicted people, the genetic profile affects their response to Methadone therapy. Therefore, this study designed to examine the frequency of two SNPs of the CYP2B6 gene (rs3745274 and rs3211371) in addicted cases in two Methadone-responders and Methadone non-responders groups. Methods: A total of 199 opioid-addicted individuals and 117 unaffected control subjects were genotyped for rs3745274 and rs3211371 polymorphisms of the CYP2B6 gene using the tetra-primer ARMS-PCR. Results: Results of this study revealed the significant association of rs3745274 GG (p < 0. 001; OR = 0. 027; 95% CI = 0. 140. 49) and GT (p < 0. 001; OR = 4. 04; 95% CI = 2. 26-7. 21) genotypes with the risk of Addiction in Methadoneresponders. Also, a significant association between rs3745274 GG (p < 0. 001; OR = 0. 28; 95% CI = 0. 15-0. 51) and GT (p < 0. 001; OR = 5. 1; 95% CI = 2. 8-5. 28) genotypes and Addiction relapse was found in Methadone nonresponders. Conclusion: Based on our findings, we can conclude that rs3745274 variant of CYP2B6 gene could serve as a potential Biomarker, to evaluate the prognosis of addicted people fate under treatment with Methadone.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

Aghabozorg Afjeh, Sara Sadat, BOSHEHRI, BEHZAD, HAMEDNIA, SAFAR, Amini, Asmaolhosna, MASHAYEKHI, PARISA, & OMRANI, MIR DAVOOD. (2021). Investigating the CYP2B6 rs3745274 and rs3211371 Polymorphisms in Methadone-Responder and Non-Responder Addicts in Iran. IRANIAN BIOMEDICAL JOURNAL, 25(3), 220-225. SID. https://sid.ir/paper/675471/en

Vancouver: Copy

Aghabozorg Afjeh Sara Sadat, BOSHEHRI BEHZAD, HAMEDNIA SAFAR, Amini Asmaolhosna, MASHAYEKHI PARISA, OMRANI MIR DAVOOD. Investigating the CYP2B6 rs3745274 and rs3211371 Polymorphisms in Methadone-Responder and Non-Responder Addicts in Iran. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2021;25(3):220-225. Available from: https://sid.ir/paper/675471/en

IEEE: Copy

Sara Sadat Aghabozorg Afjeh, BEHZAD BOSHEHRI, SAFAR HAMEDNIA, Asmaolhosna Amini, PARISA MASHAYEKHI, and MIR DAVOOD OMRANI, “Investigating the CYP2B6 rs3745274 and rs3211371 Polymorphisms in Methadone-Responder and Non-Responder Addicts in Iran,” IRANIAN BIOMEDICAL JOURNAL, vol. 25, no. 3, pp. 220–225, 2021, [Online]. Available: https://sid.ir/paper/675471/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops