OPTIMIZATION OF 67GA-OXINE PREPARATION AND LABELING OF WHITE BLOOD CELLS

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VAKILI ARIANDOKHT; JALILIAN AMIR REZA; NAZARI SONA; GHAZI ZAHEDI MARYAM; RAJABIFAR SAEED; BOLOURINOVIN FATEMEH

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Journal: Iranian Journal of Nuclear Medicine Year:2010 | Volume:18 | Issue:SUPPLEMENT 1 Page(s): 31-31

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Title

OPTIMIZATION OF 67GA-OXINE PREPARATION AND LABELING OF WHITE BLOOD CELLS

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Keywords

GALLIUM-67

OXINATE CELL

LABELING

SPECT

Abstract

Introduction: The aim of this work is Optimization of 67Ga-Oxine preparation in order to diagnostic purposes and cell LABELING. The incorporation of GALLIUM-67 into 8-hydroxyquinoline was targeted for cell LABELING due to interesting physical properties and wide availability of this nuclide as a single photon emission computed tomography (SPECT) radionuclide.Methods: GALLIUM-67 is a bioisoester of ferric iron with physical half-life of 3.3 days (78 hr) and biological half-life of 2-3 weeks. In this study, 67Ga was produced at a 30 MeV cyclotron (IBA-Cyclone 30) via the 68Zn (p, n) 67Ga reaction. Oxine has been labeled with this radionuclide in the form of [67Ga] gallium chloride for its possible diagnostic properties and the reaction conditions were optimized for time, temperature and reactant concentrations. In vitro white blood cell (WBC) LABELING was also performed.Results: The [67Ga] oxine complex was obtained at pH=5.5 in acetate buffer medium at 25°C in 2 hours.Radio-TLC showed a radiochemical purity of more than 95 ± 2%. The chemical stability of the complex was checked in vitro with a specific activity of 1432 GBq/mmol. The labeled compound was used in WBC LABELING. The cell uptake ratio was 0.12 after 120 min.Conclusion: [67Ga] (III) oxinate used in this study is a widely available agent for use in WBC LABELING studies in biology, medicine and various other research areas.

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APA: Copy

VAKILI, ARIANDOKHT, JALILIAN, AMIR REZA, NAZARI, SONA, GHAZI ZAHEDI, MARYAM, RAJABIFAR, SAEED, & BOLOURINOVIN, FATEMEH. (2010). OPTIMIZATION OF ⁶⁷GA-OXINE PREPARATION AND LABELING OF WHITE BLOOD CELLS. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 18(SUPPLEMENT 1), 31-31. SID. https://sid.ir/paper/568709/en

Vancouver: Copy

VAKILI ARIANDOKHT, JALILIAN AMIR REZA, NAZARI SONA, GHAZI ZAHEDI MARYAM, RAJABIFAR SAEED, BOLOURINOVIN FATEMEH. OPTIMIZATION OF ⁶⁷GA-OXINE PREPARATION AND LABELING OF WHITE BLOOD CELLS. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2010;18(SUPPLEMENT 1):31-31. Available from: https://sid.ir/paper/568709/en

IEEE: Copy

ARIANDOKHT VAKILI, AMIR REZA JALILIAN, SONA NAZARI, MARYAM GHAZI ZAHEDI, SAEED RAJABIFAR, and FATEMEH BOLOURINOVIN, “OPTIMIZATION OF ⁶⁷GA-OXINE PREPARATION AND LABELING OF WHITE BLOOD CELLS,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. SUPPLEMENT 1, pp. 31–31, 2010, [Online]. Available: https://sid.ir/paper/568709/en

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