Antimicrobial Effect of Phenytoin on Common Microorganisms Contaminating Oral Ulcers: An In-vitro Pilot Study

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BAHARVAND MARYAM; TABATABAEI FAHIMEH SADAT; Amiri Andi Pouya; Khodabakhshi Azin; SABOUR SIAMAK; MORTAZAVI HAMED

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Journal: Journal of Mazandaran University of Medical Sciences Year:2019 | Volume:28 | Issue:169 Page(s): 36-42

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Title

Antimicrobial Effect of Phenytoin on Common Microorganisms Contaminating Oral Ulcers: An In-vitro Pilot Study

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Keywords

phenytoinQ2

antimicrobialQ1

contaminationQ3

oral ulcerQ1

Abstract

Background and purpose The antimicrobial effect of phenytoin on ulcers has been addressed in few studies. The aim of this study was to determine the antimicrobial effect of phenytoin on common contaminating microorganisms of oral cavity ulcers in vitro. Materials and methods Three standard microbial species including Staphylococcus aureus, Actinomyces naeslundii, and Candida albicans were prepared. Twenty four-hour cultures of the species was accomplished on BHI Agar medium at 37° C in aerobic situation in an incubator. After 24 hour, 0. 5 McFarland concentration were prepared from microorganism colonies. Meadow cultivation of microorganisms was done in plates containing BHI Agar medium. In each plate 4 wells were created for 4 concentrations of phenytoin (0. 5, 1, 3, and 5%). Then one drop of each phenytoin solution was poured in the wells in certain concentrations. For each microorganism species, one well containing 0. 2% chlorhexidine was prepared as positive control. The plates were placed in incubator and after 24 hour, diameter of non-growth halo around all wells was measured in all plates using a caliper. These steps were repeated three times to ensure the accuracy of process and results. Results Diameters of non-growth halo around colonies of Staphylococcus aureus, Actinomyces naeslundii, and Candida albicans were 0 millimeter in all four concentrations of phenytoin. Conclusion phenytoin was found to have no antimicrobial effect on common contaminating microorganisms of oral cavity ulcers in vitro.

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APA: Copy

BAHARVAND, MARYAM, TABATABAEI, FAHIMEH SADAT, Amiri Andi, Pouya, Khodabakhshi, Azin, SABOUR, SIAMAK, & MORTAZAVI, HAMED. (2019). Antimicrobial Effect of Phenytoin on Common Microorganisms Contaminating Oral Ulcers: An In-vitro Pilot Study. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(169 ), 36-42. SID. https://sid.ir/paper/46113/en

Vancouver: Copy

BAHARVAND MARYAM, TABATABAEI FAHIMEH SADAT, Amiri Andi Pouya, Khodabakhshi Azin, SABOUR SIAMAK, MORTAZAVI HAMED. Antimicrobial Effect of Phenytoin on Common Microorganisms Contaminating Oral Ulcers: An In-vitro Pilot Study. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;28(169 ):36-42. Available from: https://sid.ir/paper/46113/en

IEEE: Copy

MARYAM BAHARVAND, FAHIMEH SADAT TABATABAEI, Pouya Amiri Andi, Azin Khodabakhshi, SIAMAK SABOUR, and HAMED MORTAZAVI, “Antimicrobial Effect of Phenytoin on Common Microorganisms Contaminating Oral Ulcers: An In-vitro Pilot Study,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 169 , pp. 36–42, 2019, [Online]. Available: https://sid.ir/paper/46113/en

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