AN ASSAY ON THE QUALITY OF THALLOUS CHLORIDE RADIOPHARMACEUTICAL PRODUCED IN ATOMIC ENERGY ORGANIZATION OF IRAN

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MEHRARA E.; AFARIDEH H.

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Journal: Koomesh Year:2000 | Volume:1 | Issue:3 Page(s): 41-48

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Title

AN ASSAY ON THE QUALITY OF THALLOUS CHLORIDE RADIOPHARMACEUTICAL PRODUCED IN ATOMIC ENERGY ORGANIZATION OF IRAN

Author(s)

MEHRARA E. | AFARIDEH H.

Keywords

RADIOPHARMACEUTICALQ3

QUALITY CONTROLQ4

THALLOUS CHLORIDEQ3

Abstract

Introduction: THALLOUS CHLORIDE (Tl-201) RADIOPHARMACEUTICAL is routinely used for heart imaging in nuclear medicine departments. The goal of this project was to study the quality of Tl-201 RADIOPHARMACEUTICALs produced in cyclotron department of atomic energy organization of Iran according to European and United States standards.
Materials and Methods: This RADIOPHARMACEUTICAL was produced in 15 stages through 203Tl (p,3n)201Pb→201Tl nuclear reaction in which the incident proton energy is 28 Mev. Radionuclidic impurities (203Pb,200Tl,202Tl) were determined by gamma-spectrometer with high pure Ge (HPGe) detector for production and pre-calibration dates and forone201Tl half life (73.5 hr) later. The radiochemical impurity (Tl3+ in comparison to Tl+), specific activity and activity distribution in vials were determined by electrophoresis, polarography and gamma spectrometry, and dose calibrator, respectively.
Results: In fifteen production stages radionuclidic and radiochemical purity of product and it's specific activity have been higher than 97%, 95%, and 3.7 GBq/mg-Tl respectively; But in three stages 203 Pb impurity has been higher than 0.3% determined in USP. Accuracy of activity distribution in vials was higher than 10% in all stages.
Conclusion: The results show that the product quality is in accordance to the British and European standards (BP and EP). In accordance to the United States Pharmacopoeia (USP), although in three stages of fifthteen production stages 203 Pb impurity has been higher than 0.3% determined in USP, radionuclidic purity has been acceptable (>99%).

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APA: Copy

MEHRARA, E., & AFARIDEH, H.. (2000). AN ASSAY ON THE QUALITY OF THALLOUS CHLORIDE RADIOPHARMACEUTICAL PRODUCED IN ATOMIC ENERGY ORGANIZATION OF IRAN . KOOMESH, 1(3), 41-48. SID. https://sid.ir/paper/36843/en

Vancouver: Copy

MEHRARA E., AFARIDEH H.. AN ASSAY ON THE QUALITY OF THALLOUS CHLORIDE RADIOPHARMACEUTICAL PRODUCED IN ATOMIC ENERGY ORGANIZATION OF IRAN . KOOMESH[Internet]. 2000;1(3):41-48. Available from: https://sid.ir/paper/36843/en

IEEE: Copy

E. MEHRARA, and H. AFARIDEH, “AN ASSAY ON THE QUALITY OF THALLOUS CHLORIDE RADIOPHARMACEUTICAL PRODUCED IN ATOMIC ENERGY ORGANIZATION OF IRAN ,” KOOMESH, vol. 1, no. 3, pp. 41–48, 2000, [Online]. Available: https://sid.ir/paper/36843/en

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