ASSOCIATION OF BRAIN-DEAD DONOR’S URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN LEVELS WITH KIDNEY ALLOGRAFT FUNCTION

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GANJI MOHAMMAD REZA; ALATAB SUDABEH; NADERI GHOLAMHOSSEIN; GHIYASI BAHAREH

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Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2015 | Volume:9 | Issue:5 Page(s): 394-399

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Information Journal Paper

Title

ASSOCIATION OF BRAIN-DEAD DONOR’S URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN LEVELS WITH KIDNEY ALLOGRAFT FUNCTION

Author(s)

GANJI MOHAMMAD REZA | ALATAB SUDABEH | NADERI GHOLAMHOSSEIN | GHIYASI BAHAREH | Issue Writer Certificate

Keywords

KIDNEY TRANSPLANTATION

BRAIN DEATH

DELAYED GRAFT FUNCTION

LIPOCALINS

Abstract

Introduction: Development of DELAYED GRAFT FUNCTION is more prevalent in patients receiving a kidney allograft from brain-dead than living donors. This study aimed to evaluate the association between urine neutrophil gelatinase-associated lipocalin (NGAL) levels in brain-dead donors and subsequent allograft function.Materials and Methods: Urine NGAL concentration was measured in urine samples obtained from 24 brain-dead kidney allograft donors before organ retrieval. The 24 kidney recipients were followed for 6 months. The immunosuppressive therapy was similar for all of the recipients. Following transplantation, plasma creatinine was recorded daily during the recipient’s stay in the hospital and then at 1, 3, and 6 months after transplantation. DELAYED GRAFT FUNCTION was defined as the need for dialysis in the first 7 days after transplantation.Results: The mean age of the donors was 28.7 ± 11.2 years and 70.8% were men. Their median urine NGAL level was 7.4 ng/ml (range, 2 ng/mL to 45 ng/mL). Urine NGAL levels were only associated with the need for cardiopulmonary resuscitation (P=.007). On the 1st day after transplantation, 16.7% of the recipients developed DELAYED GRAFT FUNCTION, which was declined to 12.5% on the 2nd day and to 8.3% during the 3rd day and the following days. No significant association was observed between the donor’s urine NGAL levels and graft function (P=.86).Conclusions: Our results did not show any association between urine NGAL levels and outcome of allograft function obtained from brain-dead donors. Larger studies are required to confirm this finding.

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APA: Copy

GANJI, MOHAMMAD REZA, ALATAB, SUDABEH, NADERI, GHOLAMHOSSEIN, & GHIYASI, BAHAREH. (2015). ASSOCIATION OF BRAIN-DEAD DONOR’S URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN LEVELS WITH KIDNEY ALLOGRAFT FUNCTION. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 9(5), 394-399. SID. https://sid.ir/paper/309476/en

Vancouver: Copy

GANJI MOHAMMAD REZA, ALATAB SUDABEH, NADERI GHOLAMHOSSEIN, GHIYASI BAHAREH. ASSOCIATION OF BRAIN-DEAD DONOR’S URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN LEVELS WITH KIDNEY ALLOGRAFT FUNCTION. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2015;9(5):394-399. Available from: https://sid.ir/paper/309476/en

IEEE: Copy

MOHAMMAD REZA GANJI, SUDABEH ALATAB, GHOLAMHOSSEIN NADERI, and BAHAREH GHIYASI, “ASSOCIATION OF BRAIN-DEAD DONOR’S URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN LEVELS WITH KIDNEY ALLOGRAFT FUNCTION,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 9, no. 5, pp. 394–399, 2015, [Online]. Available: https://sid.ir/paper/309476/en

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