مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

444
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

372
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

EVALUATION OF ENDOCRINE DISORDERS IN PATIENTS WITH THALASSEMIA MAJOR

Pages

  104-113

Abstract

 THALASSEMIA MAJOR is a genetic disorder and blood transfusion is critical for survival in these patients. Over the course of the past three decades, hyper transfusion therapy in these patients has shown significant increase in life expectancy and quality of life. Unfortunately this type of therapy also increased the frequency of complications due to iron overload. The aim of this study was to evaluate the prevalence of endocrine disturbances in patients, aged over 10 years, with THALASSEMIA MAJOR.Materials and Methods: Fifty six patients, aged over 10 years, with THALASSEMIA MAJOR were enrolled. Physicians collected demographic data and history of therapies as well as menstrual histories in females. Patients were examined to determine their pubertal status and SDS of height for evaluation of short stature. For evaluation of glucose tolerance, fasting blood glucose and oral glucose tolerance tests were performed. Serum levels were measured for calcium, phosphorous, thyroid stimulating hormone, free thyroxin, luteinizing hormone, follicular stimulating hormone, and estradiol and testosterone in girls and boys respectively.Results: Fifty-six patients with THALASSEMIA MAJOR, aged between 10-27 years, were evaluated. In this study prevalences of DIABETES MELLITUS, IMPAIRED FASTING GLUCOSE and IMPAIRED GLUCOSE TOLERANCE TEST were 8.9%, 28.6% and 7.1% respectively. Short stature (SDS :S;-2)was seen in 70% of boys and in 73% of girls. HYPOCALCAEMIA and primary overt HYPOTHYROIDISM were present in 41% and 16% respectively; 14.3% of our patients had no endocrine abnormalities. Conclusion: Despite recent therapy with Desferal in the management of beta-THALASSEMIA MAJOR, the risk of secondary endocrine dysfunction remains high. HYPOGONADISM is one of the most frequent endocrine complications. Endocrine evaluation in patients with THALASSEMIA MAJOR must be carried out regularly especially in those patients over the age of 10 years, in Tabriz.

Multimedia

  • No record.

    • Cites

    References

  • No record.

    • Cite

    APA: Copy

    NAJAFIPOUR, F.. (2008). EVALUATION OF ENDOCRINE DISORDERS IN PATIENTS WITH THALASSEMIA MAJOR. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 6(2), 104-113. SID. https://sid.ir/paper/297376/en

    Vancouver: Copy

    NAJAFIPOUR F.. EVALUATION OF ENDOCRINE DISORDERS IN PATIENTS WITH THALASSEMIA MAJOR. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2008;6(2):104-113. Available from: https://sid.ir/paper/297376/en

    IEEE: Copy

    F. NAJAFIPOUR, “EVALUATION OF ENDOCRINE DISORDERS IN PATIENTS WITH THALASSEMIA MAJOR,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 6, no. 2, pp. 104–113, 2008, [Online]. Available: https://sid.ir/paper/297376/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button