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Information Journal Paper

Title

EFFECT OF GALLIC ACID AND ENDURANCE EXERCISE TRAINING ON BDNF IN A MODEL OF HIPPOCAMPAL DEGENERATION

Pages

  1-6

Abstract

 Introduction: The aim of this study was to investigate the effect of gallic acid on hippocampal level of brain derivative neurotrophic factor (BDNF) in trimethyltin chloride (TMT) - intoxication rats after eight weeks of endurance training.Materials and Methods: Seventy Sprague-dawley male rats were selected and randomly divided into seven groups, including: (1) Control, (2) Sham, (3) Gallic acid 50, (4) Gallic acid 100, (5) Endurance training (4), (6) Training+Gallic acid 50, and (7) Training+Gallic acid 100.Hippocampal degeneration was induced by TMT (8 mg/kg) in all groups except control animals. During eight weeks, rats of groups 3, 6 and 7 ran on treadmill’s without incline at a speed of 15 to 20 meters per minute for 15 to 30 minutes per session, five times weekly.In addition, groups 4 and 6 were treated with gallic acid (50 mg/kg) and groups 5 and 7 with gallic acid (100 mg/kg) every day for 14 days.Results: The findings showed that hippocampal levels of BDNF in all test groups was significantly higher than sham group.Conclusion: Endurance training and gallic acid as well as the combination of them increase the level of hippocampal BDNF in a model of TMT-intoxication.

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    APA: Copy

    RAFIEI, SAMANEH, BAZYAR, YUNES, & EDALATMANESH, MOHAMMAD AMIN. (2016). EFFECT OF GALLIC ACID AND ENDURANCE EXERCISE TRAINING ON BDNF IN A MODEL OF HIPPOCAMPAL DEGENERATION. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 4(1), 1-6. SID. https://sid.ir/paper/258085/en

    Vancouver: Copy

    RAFIEI SAMANEH, BAZYAR YUNES, EDALATMANESH MOHAMMAD AMIN. EFFECT OF GALLIC ACID AND ENDURANCE EXERCISE TRAINING ON BDNF IN A MODEL OF HIPPOCAMPAL DEGENERATION. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2016;4(1):1-6. Available from: https://sid.ir/paper/258085/en

    IEEE: Copy

    SAMANEH RAFIEI, YUNES BAZYAR, and MOHAMMAD AMIN EDALATMANESH, “EFFECT OF GALLIC ACID AND ENDURANCE EXERCISE TRAINING ON BDNF IN A MODEL OF HIPPOCAMPAL DEGENERATION,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 4, no. 1, pp. 1–6, 2016, [Online]. Available: https://sid.ir/paper/258085/en

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