Adherence to Immunosuppressants among Adult Patients after Allogeneic Hematopoietic Stem-Cell Transplantation (Allo-HSCT): A Cross-Sectional Study

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Derakhshan Atefe; MANSOURI AVA; JAFARZADEH KOHNELOO Aarefeh; HADJIBABAIE MOLOUK

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Journal Paper

Paper Information

Journal: International Journal of Hematology-Oncology and Stem Cell Research Year:2023 | Volume:17 | Issue:4 Page(s): 231-239

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Information Journal Paper

Title

Adherence to Immunosuppressants among Adult Patients after Allogeneic Hematopoietic Stem-Cell Transplantation (Allo-HSCT): A Cross-Sectional Study

Author(s)

Derakhshan Atefe | MANSOURI AVA | JAFARZADEH KOHNELOO Aarefeh | HADJIBABAIE MOLOUK | Issue Writer Certificate

Keywords

Medication Adherence

Treatment Adherence and Compliance

Immunosuppressive Agents

Transplantation

Homologous

Hematopoietic Stem Cell Transplantation

Cyclosporine

Abstract

Background: The level of adherence to drug therapy after allogeneic hematopoietic stem-cell Transplantation (Allo-HSCT) can affect the patient’, s outcome, and poor adherence is one of the factors in first-year mortality after HSCT. Material and Methods: This study assessed adherence to Cyclosporine and prednisolone as the immunosuppressant regimen in 110 post-HSCT patients (> 18 years). Demographic characteristics, clinical information, and Cyclosporine levels were obtained. A validated Persian Medication Adherence scale was used to assess adherence to Cyclosporine and prednisolone. Results: For 110 patients, the calculated mean of the total score of Cyclosporine and prednisolone was 7. 73 ±,0. 62 and 7. 63 ±,0. 73, respectively. Poor adherence to medication in this population was 27. 7% and 22. 7% to prednisolone and Cyclosporine, respectively. A significant correlation was observed between adherence total score and Cyclosporine levels at the third-and fourth-month post-transplant (r = 0. 52, P < 0. 001 and r = 0. 60, P = 0. 001). In the first, second, and third months, the mean of Cyclosporine levels in the high adherence level was higher than the moderate and poor adherence levels. Additionally, there was an association between adherence score and the level of Cyclosporine. One score increase in adherence scale on average increased Cyclosporine level by 34. 48 ng/ml. Conclusion: In this study, medication non-adherence was high, which indicates the need for more careful monitoring of post-HSCT patients’,medication use. This is even more crucial currently since it has been confirmed that adherence can affect Cyclosporine levels as the most effective immunosuppressant agent in preventing graft-versus-host disease (GVHD).

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APA: Copy

Derakhshan, Atefe, MANSOURI, AVA, JAFARZADEH KOHNELOO, Aarefeh, & HADJIBABAIE, MOLOUK. (2023). Adherence to Immunosuppressants among Adult Patients after Allogeneic Hematopoietic Stem-Cell Transplantation (Allo-HSCT): A Cross-Sectional Study. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), 17(4), 231-239. SID. https://sid.ir/paper/1135879/en

Vancouver: Copy

Derakhshan Atefe, MANSOURI AVA, JAFARZADEH KOHNELOO Aarefeh, HADJIBABAIE MOLOUK. Adherence to Immunosuppressants among Adult Patients after Allogeneic Hematopoietic Stem-Cell Transplantation (Allo-HSCT): A Cross-Sectional Study. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)[Internet]. 2023;17(4):231-239. Available from: https://sid.ir/paper/1135879/en

IEEE: Copy

Atefe Derakhshan, AVA MANSOURI, Aarefeh JAFARZADEH KOHNELOO, and MOLOUK HADJIBABAIE, “Adherence to Immunosuppressants among Adult Patients after Allogeneic Hematopoietic Stem-Cell Transplantation (Allo-HSCT): A Cross-Sectional Study,” INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), vol. 17, no. 4, pp. 231–239, 2023, [Online]. Available: https://sid.ir/paper/1135879/en

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