This tumor is uncommon but found in ox, Sheep and dog and less commonly in the cat, pig and horse. In Great Britain hepatocellular carcinoma (HCC) comprises 20 percent of all tumors found in slaughtered Sheep. Affected animals are usually adult, though hepatoma has been found even in newborn lambs, this tumor appeared to be congenital origin but mostly described in older lambs (Molton 1978, Cotchin 1984). The incidence for this tumor is usually between 4 and 8 years in cows and over one year (often 4-5 years) in Sheep (Molton 1978). In a 12 month surveys of neoplasm found in 100 abattoirs throughout Great Britain in Sheep 32 of 107 tumors originated in the liver, 8 of these tumors were found in younger than one and 24 in older than one year Sheep (Anderson & Sandison 1968).

At necropsy of a five-year-old Sheep, a pear shaped, lobular yellow-brownish mass measuring about 12x15x20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecular and solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells that contain one or more large hyperchromatic bizarre-shaped nuclei scattered among clusters of neoplastic hepatocytes. In addition, mitotic figures, dilated sinusoids and large vascular spaces filled with red blood cells were observed in some sections. Based on gross and histopathologic characteristics, the mass was diagnosed as hepatocellular carcinoma.

Objective: Anatomical and histological studies of VNO in Lori Sheep.Samples: Twenty-one of Lori Sheep heads were used.Procedure: VNO of Lori Sheep prepared and fixed in fixative solution then processed for tissue sectioning. For histological observation using H&E technique. Biometrical parameters of VNO were evaluated.Results: The mean length of VNO was 90.645.96mm. This organ is encapsulated in cartilaginous capsule that in most portion incompleted but in small portion completed. In histological study of VNO showed that the epithelium linning the lumen of VNO were of two different kinds i.e: pseudostratified ciliated columnar epithelium (Respiratory) in lateral wall and pseudo stratified nonciliated columnar (Receptory) in medial wall of lumen.

We report the occurrence of lung cancer in a six months old lamb of Ouled Djellal breed from Algeria. The main clinical sign was a considerable amount of whitish foamy fluid discharge from the nostrils when the animal head was lowered and the rear end was lifted. The postmortem examination revealed the presence of enlarged, heavy and edematous lungs with diffuse or foci areas, reddish or white-gray in color. The gross and histological lesions of the lungs were compatible with pulmonary adenocarcinoma. Lung adenocarcinoma in Sheep is caused by jaagsiekte Sheep retrovirus (JSRV) and originated from differentiated alveolar type II cells and non-ciliated bronchiolar epithelial Clara cells. We evidenced the expression of the oncogenic JSRV by immunostaining of lung slides with specific antibodies against the JSRV envelope. The viral proteins were expressed only in the tumor cells from the affected areas. As already described in other countries, JSRV-induced lung adenocarcinoma is present in the Sheep population in Algeria.