Purpose: This study was conducted with a holistic approach to reviewing and redefining the process of interaction with information. Method: Data was collected by semi-structured interviews with 18 social and humanities researchers and analyzed by thematic analysis. Findings: Thematic network of information interactions consists of 5 global themes. In this network, with symmetry as one of the global themes, we found four other themes, ie opening, orientation, networking, and consolidation. Symmetry results in a relatively balanced view on the influence of human and nonhuman in information interactions. It prevents human or nonhuman agents to exert absolute domination of the interaction. In the symmetric model of information interactions, three layers of contexts, including internal-cognitive context, externalenvironmental contexts, and technology-tool are decisive. Conclusion: The new view of interacting with information goes beyond mere interpretation from the perspective of the human user and sees it alongside in human factors. As a result of such an approach, non-human factors in the role of infrastructure and technology context, along with human factors, external and internal context have clear and interpretable effects.