Fish tank or swimming GRANULOMA caused by Mycobacterium marinum is an opportunist pathogen commonly found in aquatic environments. We present a 16 year-old boy with frequent exposure to aquarium water who had several nodules (sprotrichoid forms) on his right hand.Pervious studies showed that fish tank GRANULOMA is a rare skin infection (0.27 per 100,000 population in one year). However, taking proper history and considering the patient’s signs and symptoms could be helpful in diagnosis and treatment.

Common variable immunodeficiency is a primary immunodeficiency disorder characterized by decreased level of circulating immunoglobulins and increased risk of bacterial infection, autoimmune, and GRANULOMAtous disease. One of the most striking complications of CVID is GRANULOMAtous disease, which can be confused with sarcoidosis, tuberculosis, chronic GRANULOMAtous disease and etc. In this article we report a case of GRANULOMAtous CVID diagnosed in a 21 year old woman and discuss relation between CVID and GRANULOMAtous reactions.

GRANULOMA annulare is self-limiting cutaneous condition of unknown etiology, causing necrobiotic dermal and subcutaneous papules. A number of conditions have been described in association with GRANULOMA annulare, including lymphoma, anemia, intestinal bleeding, seronegative arthralgia, vasculitis and autoimmune thyroiditis. This manuscript, as the first report of this combination in Iran, describes an unusual case of relapsing, concomit

The patient is a seventeen years old girl, with severe pain and swelling in right maxillary sinus region and facial deformity from two weeks prior to referring. CT scan demonstrated a large tumoral mass in right maxillary sinus extended to petereigomaxillary fossa, orbital floor, lacrimal system and nasoethmoid region. Hard palate had been destroyed and bulged in to the oral cavity. Tumor was resected completely by radical cald-well-Iuck approach. Hystopathology of tumor was giant cell reparative GRANULOMA (G.C.R.G), which is a very rare tumor in paranasal sinuses. Since the association of these tumors with hyperparathyroidism has been reported in literature, the patient was evaluated for hyperparathyroidism and elevated serum parathyroid hormone (PTH: 390 pg/ml) and other hematological tests confirmed secondary hyperparathyroidism.

GRANULOMA annulare (GA) is an inflammatory benign cutaneous disease of unknown etiology that may manifest different clinical features. The most common presentation or classic form of the disease is manifested as flesh colored, annular grouped papules, commonly involving the hands and feet. Various skin injuries and infections have been reported to trigger GA, including insect bites, warts, herpes zoster, acquired immunodeficiency syndrome and Epstein-Barr virus infections. Several clinical manifestations have been reported for this disease such as localized, generalized, subcutaneous, linear, and perforating and patch GA, have been reported. Linear form is a rare variant of localized GA, and other skin diseases occurring in a linear configuration such as rheumatoid nodule, wart, morphea, and epidermal nevus must be differentiated from linear GA. This report describes a case of a 3 cm linear, flesh-colored, lesion with beaded border on dorsum of right index finger in a 8-year-old girl with histological findings of GA.

Central giant cell GRANULOMA, (giant cell reparative GRANULOMA), is a non-neoplastic proliferative lesion with unknown etiology which commonly occurs in the mandible. This lesion presents a wide variety of radiological and clinical manifestations that may lead to misdiagnosis. CGCG is diagnosed through histopathological examinations.

Purpose: To report a case of free floating pyogenic GRANULOMA within the lacrimal sac.Case Report: A 13 month old infant with unresolving dacryocystitis and history of two times failed probing and once failed turbinate fracture was scheduled for dacryocystorhinostomy (DCR). A free floating red mass was removed from the sac. Histopathologic examination confirmed a diagnosis of pyogenic GRANULOMA.Eight months after the operation the patient was asymptomatic.Conclusion: When probing of the lacrimal duct fails to improve its obstruction, in addition to nasal lesions, lacrimal sac masses including pyogenic GRANULOMA must be considered.

From 1996-1998 in Imam Reza medical center infants umbilical GRANULOMA treatment with salt and silver nitrate studied prospectively, comparative and unaccidently.20 infants were in salt group and 19 infants were in silver sitrat group.In these two groups the patient's sex, weight-age-pariety-umblicle cord separation age of GRANULOMA presentation were not statically signicant.Response to treatment in salt and silver nitrat groups were 2.1 and 3.36 times respectively (2-taile p=0.0000).This study showed that umbilical GRANULOMA treatment with salt is cheapper, available and more effective than silver nitrat. And treatment complications in silver groop were more than salt group.

Purpose: To report two rare cases of orbital cholesterol GRANULOMA (CG) presenting with ptosis and proptosis. Methods: The first case was a 31-year-old male presented with progressive ptosis of the left eye (LE) during the past year and the second case was a 35-year-old male presented with proptosis of the right eye (RE) for 5 months ago. Orbital computed tomography revealed a cystic well-demarcated lesion in the superotemporal orbit with adjacent bone erosion in the LE of the first case and the RE of the second case. Results: In both cases, the tumor was excised completely through an anterolateral orbitotomy approach. Histopathological evaluation showed fibroconnective tissue with cholesterol clefts surrounded by GRANULOMAtous inflammation consistent with the diagnosis of CG. The symptoms of patients were resolved after surgery. Conclusions: CG of the orbit is a rare lesion that commonly occurred in the superotemporal area. Erosive bone expansion is the characteristic finding of this lesion that can be mistaken with lacrimal gland malignancies. Hence, it is essential to keep CG in mind in the differential diagnosis of lacrimal gland masses.