Global trends like increasing healthcare costs, changes in patient demands, and technology developments have led to healthcare system moving towards eHealth. In many cases of eHealth implementation, there is a large gap between expected outcomes and what happened in reality. The studies emphasized many of these failures were due to an inadequate understanding of factors influencing on eHealth implementation and the lack of a comprehensive framework to apply such interventions. On the other hand, legal, clinical and economic requirements have made eHealth a priority for Iran's healthcare system in recent years. The purpose of this study is the explanation of the multi-level complexity of eHealth implementation as well as the provision of a research program and guidance on using eHealth. This purpose is fulfilled through a meta-synthesis of eHealth literature in Persian, and synthesizing collected data into a system model. Totally, 221 unique researches were obtained from the databases, of which 56 were identified as relevant in the initial survey. In the meta-synthesis of relevant researches, 39 components had been identified as eHealth requirements in eight major financial-economic, legal, technological, security, social, attitudinal, educational, and ethical components. In addition, 13 elements were extracted as eHealth outcomes in the economic, legal, positive and negative clinical categories. Among the requirements for eHealth system implementation, the security component and the ethical component had the highest and lowest amount of attention in the literature, respectively. However, for the practical realization of the eHealth system, all these requirements have to be addressed. The outcomes of this system are also used in targeting future eHealth projects and designing evaluation metrics and indicators for ongoing eHealth implementation projects.