Smart packages provide information of the state of the packaged food to the consumer by using materials that monitor and interact with the packaging environment, through an internal or external indicator. The use of artificial colors, as indicators of food freshness in food packaging, not only have toxic, carcinogenic and mutagenic properties, but also threaten the health of consumers and the environment, and in addition, they are also not suitable for application in food industries. But nature-based materials can be a suitable alternative to be used as indicators and sensors. Therefore, the purpose of writing of this article is to review the latest information about biosensors made based on compounds obtained from natural extracts in food packaging. Obviously, bioactive extracts based on anthocyanins, betalins, and Curcumins obtained from natural sources, including byproducts of food industry, have significant potential to function as biosensors.