SYNTHESIS OF BOC-HISTIDINE GRAFTED DEXTRAN WITH MICELLE FORMATION ABILITY

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Jafarzadeh Holagh Samira; VASHEGHANI FARAHANI EBRAHIM; HASHEMI NAJAFABADI SAMIREH

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Seminar: IRANIAN CHEMISTRY CONGRESS
Year:2015 | Issue:18

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Title

SYNTHESIS OF BOC-HISTIDINE GRAFTED DEXTRAN WITH MICELLE FORMATION ABILITY

Author(s)

Jafarzadeh Holagh Samira | VASHEGHANI FARAHANI EBRAHIM | HASHEMI NAJAFABADI SAMIREH | Issue Writer Certificate

Keywords

DEXTRAN

BOC-HIS-OH

MICELLE

DRUG DELIVERY

Abstract

BACKGROUND: IN THE LAST TWO DECADES, POLYMERIC MICELLES HAVE ATTRACTED CONSIDERABLE INTEREST ESPECIALLY FOR DELIVERING ANTITUMOR DRUGS TO SOLID TUMORS, WHICH COULD BE SELF-ASSEMBLED FROM AMPHIPHILIC GRAFT COPOLYMERS. MATERIAL USED FOR THIS MICELLE SHOULD BE BIOCOMPATIBLE. AMONG POLYMERS USED IN THIS APPLICATION, POLYSACCHARIDE ATTRACT MANY ATTENTION BECAUSE OF THEIR BIOCOMPATIBILITY, BIODEGRADABILITY, CELL SURFACE RECOGNITION SITES [1] AND A LARGE NUMBER OF REACTIVE GROUPS ON THEIR STRUCTURE WHICH SIMPLIFIES TO MODIFY THE STRUCTURE TO CREATE DESIRED PROPERTIES. IN THIS STUDY DEXTRAN (DEX) WAS CHOSEN AS A HYDROPHILIC BACKBONE DUE TO ALL PROPERTIES NOTICED FOR POLYSACCHARIDE AND HAD ALREADY BEEN USED IN CLINICAL APPLICATIONS. MOREOVER, DUE TO THE 5% BRANCHING STRUCTURE AS WELL AS PLENTIFUL OF HYDROXYL GROUPS ON THE CHAINS, DEXTRAN CAN EASILY BE CHEMICALLY MODIFIED [2]. IN THIS CONTRIBUTION, BOC-HISTIDINE-GRAFTED DEXTRAN (DEX-HIS) WAS SYNTHESIZED VIA AN ESTERIFICATION REACTION. CRITICAL MICELLE CONCENTRATION (CMC) IS AN IMPORTANT CHARACTERISTIC FOR AMPHIPHILIC MATERIALS WAS DETERMINED FOR MICELLE FORMATION ABILITY...

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APA: Copy

Jafarzadeh Holagh, Samira, VASHEGHANI FARAHANI, EBRAHIM, & HASHEMI NAJAFABADI, SAMIREH. (2015). SYNTHESIS OF BOC-HISTIDINE GRAFTED DEXTRAN WITH MICELLE FORMATION ABILITY. IRANIAN CHEMISTRY CONGRESS. SID. https://sid.ir/paper/931937/en

Vancouver: Copy

Jafarzadeh Holagh Samira, VASHEGHANI FARAHANI EBRAHIM, HASHEMI NAJAFABADI SAMIREH. SYNTHESIS OF BOC-HISTIDINE GRAFTED DEXTRAN WITH MICELLE FORMATION ABILITY. 2015. Available from: https://sid.ir/paper/931937/en

IEEE: Copy

Samira Jafarzadeh Holagh, EBRAHIM VASHEGHANI FARAHANI, and SAMIREH HASHEMI NAJAFABADI, “SYNTHESIS OF BOC-HISTIDINE GRAFTED DEXTRAN WITH MICELLE FORMATION ABILITY,” presented at the IRANIAN CHEMISTRY CONGRESS. 2015, [Online]. Available: https://sid.ir/paper/931937/en

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