DETERMINATION OF PHENOBARBITAL IN PHARMACEUTICAL SAMPLE BY DERIVATIVE SPECTROPHOTOMETRY METHOD

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SHEIBANI -; ZAINADINI M.

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Seminar Paper

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Seminar: IRANIAN CHEMISTRY CONGRESS
Year:2013 | Issue:16

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Title

DETERMINATION OF PHENOBARBITAL IN PHARMACEUTICAL SAMPLE BY DERIVATIVE SPECTROPHOTOMETRY METHOD

Author(s)

SHEIBANI - | ZAINADINI M. | Issue Writer Certificate

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Abstract

ANALYTICAL METHODS BASED ON MEASUREMENTS OF UV-VIS ABSORPTION BELONG TO THE MOST POPULAR AND MOST OFTEN USED IN LABORATORY PRACTICE. THE MAIN DISADVANTAGE AND LIMITATION OF THE SPECTROPHOTOMETRY IS ITS LOW SELECTIVITY. ONE OF THE SIMPLEST METHODS FOR INCREASING SELECTIVITY IS DERIVATISATION OF SPECTRA. THIS OPERATION ALLOWS TO REMOVE SPECTRAL INTERFERENCES AND AS A CONSEQUENCE LEADS TO INCREASE SELECTIVITY OF ASSAY [1].PHENOBARBITAL IS A SUBSTITUTED BARBITURIC ACID THAT ACTS AS A NONSELECTIVE CENTRAL NERVOUS SYSTEM DEPRESSANT, AND IS WIDELY USED AS ANTIEPILEPTIC DRUG DUE TO ADVANTAGES INCLUDING RELIABILITY OF SUPPLY, AFFORDABLE COST, BROAD SPECTRUM OF ACTION, AND EASE OF USE [3, 4]. IN THIS STUDY, A RAPID AND SENSITIVE DERIVATIVE SPECTROPHOTOMETRIC METHOD WAS DEVELOPED FOR THEDETERMINATIONOF PHENOBARBITAL. THEEFFECTIVE PARAMETERS ON THE DETERMINATION OF PHENOBARBITAL SUCH AS DERIVATIVE ORDER, TEMPERATURE AND PH WERE INVESTIGATED AND OPTIMIZED. UNDER OPTIMIZED CONDITIONS (SECOND DERIVATIVE, PH=2-3, T=30-40OC), CALIBRATION CURVE WAS OBTAINED OVER THE RANGE 1.63 OF 40 MG/ML OF ANALYTE. THE LIMIT OF DETECTION OF PHENOBARBITAL WAS 0.96 MG/ML. REPRODUCIBILITY OF THE METHOD AS THE RELATIVE STANDARD DEVIATION WAS 1.1%. THE CAPABILITY OF THE PROPOSED METHOD WAS TESTED ON THE DETERMINATION OF PHENOBARBITAL IN TABLET AS A PHARMACEUTICAL SAMPLE THAT SATISFACTORY RESULTS WERE OBTAINED.

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APA: Copy

SHEIBANI, -, & ZAINADINI, M.. (2013). DETERMINATION OF PHENOBARBITAL IN PHARMACEUTICAL SAMPLE BY DERIVATIVE SPECTROPHOTOMETRY METHOD. IRANIAN CHEMISTRY CONGRESS. SID. https://sid.ir/paper/913625/en

Vancouver: Copy

SHEIBANI -, ZAINADINI M.. DETERMINATION OF PHENOBARBITAL IN PHARMACEUTICAL SAMPLE BY DERIVATIVE SPECTROPHOTOMETRY METHOD. 2013. Available from: https://sid.ir/paper/913625/en

IEEE: Copy

- SHEIBANI, and M. ZAINADINI, “DETERMINATION OF PHENOBARBITAL IN PHARMACEUTICAL SAMPLE BY DERIVATIVE SPECTROPHOTOMETRY METHOD,” presented at the IRANIAN CHEMISTRY CONGRESS. 2013, [Online]. Available: https://sid.ir/paper/913625/en

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