SYNTHESIS OF BIODEGRADABLE POLYESTER NANOCAPSULESCONTAING CORTICOSTEROIDS

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HOSSEINZADEH M.; AMIRI R.

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Seminar Paper

Paper Information

Seminar: IRANIAN SEMINAR OF ORGANIC CHEMISTRY
Year:2014 | Issue:22

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Title

SYNTHESIS OF BIODEGRADABLE POLYESTER NANOCAPSULESCONTAING CORTICOSTEROIDS

Author(s)

HOSSEINZADEH M. | AMIRI R. | Issue Writer Certificate

Keywords

SYNTHESIS

BIODEGRADABLE

NANOCAPSULATION

Abstract

IN THE FIELD, POLYMERIC NANOPARTICLES HAVE BEEN EXTENSIVELY STUDIED AS PARTICULATE CARRIERS IN THE PHARMACEUTICAL AND MEDICAL FIELD. IN THIS INVESTIGATION, THE LIPID-CORE NANOCAPSULES WERE PREPARED BY INTERFACIAL DEPOSITION OF PREFORMED POLYMER. PCL, SUNFLOWER SEED OIL, PVA (POLYVINYL ALCOHOL), AND CORTISONE WERE DISSOLVED AT AMBIENT TEMPERATURE IN SUITABLE SOLVENT. THE ADVANTAGE OF THESE POLYESTERS IS THEIR BIOCOMPATIBILITY AND HIGHER HYDROLYSIS ABILITY INTO HUMAN BODY. MAJOR ACTIVITY IN THIS AREA HAS CENTERED ON ALIPHATIC POLYESTERS, PRINCIPALLY DUE TO THE FAVORAB TOXICOLOGY OF THEIR DEGRADATION PRODUCT BY UV, FT-IR AND SEM TECHNIQUES AND THEIR SUPERNATANT WERE USED FOR THE SPECTROSCOPIC SCAN ANALYSIS FROM 190 TO 800 NM. SEM CHARACTERISATION OF CORTISONE LOADED PCL NANOPARTICLES (FIG. A) AND PCL NANOPARTICLES (FIG. B). THE PARTICLE SIZE AND POLY DISPERSITY INDICES WERE MEASURED BY PHOTON CORRELATION SPECTROSCOPY. CORTISONE LOADED PCL NANOPARTICLES HAVE -24.5 MV ZETA POTENTIAL.CRITERIA FOR SELECTING A METHOD FOR PREPARATION OF NANOCAPSULES ACCORDING TO ITS ADVANTAGES, LIMITATIONS ANDBEHAVIOURS AS A DRUG CARRIER. [1-2]

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APA: Copy

HOSSEINZADEH, M., & AMIRI, R.. (2014). SYNTHESIS OF BIODEGRADABLE POLYESTER NANOCAPSULESCONTAING CORTICOSTEROIDS. IRANIAN SEMINAR OF ORGANIC CHEMISTRY. SID. https://sid.ir/paper/913282/en

Vancouver: Copy

HOSSEINZADEH M., AMIRI R.. SYNTHESIS OF BIODEGRADABLE POLYESTER NANOCAPSULESCONTAING CORTICOSTEROIDS. 2014. Available from: https://sid.ir/paper/913282/en

IEEE: Copy

M. HOSSEINZADEH, and R. AMIRI, “SYNTHESIS OF BIODEGRADABLE POLYESTER NANOCAPSULESCONTAING CORTICOSTEROIDS,” presented at the IRANIAN SEMINAR OF ORGANIC CHEMISTRY. 2014, [Online]. Available: https://sid.ir/paper/913282/en

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